Evidence map›Paper›PMID 28355561›Full record

ArticleCell reports2017

Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.

Taylor Eddens, Waleed Elsegeiny, Maria de la Luz Garcia-Hernadez, Patricia Castillo, Giraldina Trevejo-Nunez, Katelin Serody, Brian T Campfield, Shabaana A Khader, Kong Chen, Javier Rangel-Moreno and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 81 citations in OpenAlex.

  1. Contextualizing TNature reviews. Immunology · 2026
    Review
  2. Antioxidants (Basel, Switzerland) · 2026
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  5. Review
  6. Review
  7. Review
  8. Frontiers in immunology · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. CD4Immunology and cell biology · 2025
    Review
  13. Review
  14. Review
  15. Immune responses of different hosts toEuropean respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  16. Article
  17. T-cell subsets inClinical & translational immunology · 2025
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Taylor EddensRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
Waleed ElsegeinyRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
Maria de la Luz Garcia-HernadezAab Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14624, USA.
Patricia CastilloRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
Giraldina Trevejo-NunezRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
Katelin SerodyRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
Brian T CampfieldDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Shabaana A KhaderDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kong ChenRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
Javier Rangel-MorenoDepartment of Medicine, Allergy/Immunology, and Rheumatology, University of Rochester, Rochester, NY 14624, USA.
Jay K KollsRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. Electronic address: jay.kolls@chp.edu.
Children's Hospital of Pittsburgh · USUniversity of Rochester · USRichard King Mellon Foundation · USUniversity of Pittsburgh · USWashington University in St. Louis · US

Funding

ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1M
T-Cells and P. Carinii PneumoniaR01HL062052 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 1998 to 2017
$5.1M
Improved Therapeutics and Diagnostics for PneumocystisPneumoniaR01AI120033 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAY K KOLLS · 2016 to 2026
$4.8M
A Critical Role for Follistatin-like Protein-1 in Lung HomeostasisK08HL128809 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMPFIELD, BRIAN T · 2015 to 2019
$675k
Antigen discovery and validation in Pneumocystis pneumoniaF30AI114146 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EDDENS, TAYLOR JOHN · 2014 to 2017
$189k
NHLBI NIH HHS K08 HL128809NHLBI NIH HHS R01 HL062052NIAID NIH HHS F30 AI114146NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI120033
6 · The paper itself

Abstract

Inducible bronchus-associated lymphoid tissue (iBALT) is an ectopic lymphoid structure composed of highly organized T cell and B cell zones that forms in the lung in response to infectious or inflammatory stimuli. Here, we develop a model for fungal-mediated iBALT formation, using infection with Pneumocystis that induces development of pulmonary lymphoid follicles. Pneumocystis-dependent iBALT structure formation and organization required CXCL13 signaling. Cxcl13 expression was regulated by interleukin (IL)-17 family members, as Il17ra

Indexed as

ImmunityAnimalsBronchiChemokine CXCL13GATA3 Transcription FactorInterleukin-13Interleukin-17Lymphoid TissueLymphotoxin-alphaMice, Inbred BALB CMice, Inbred C57BLPneumocystisPneumocystis InfectionsReceptors, CXCR5Receptors, Interleukin-17Signal TransductionChemokine CXCL13CXCR5 protein, mouseGATA3 Transcription FactorInterleukin-13Interleukin-17Lymphotoxin-alphaReceptors, CXCR5Receptors, Interleukin-17STAT3 Transcription FactorCxcl13fungusiBALTimmunitylymphoid tissuePneumocystisTh17Th2

Identifiers

PMID28355561
PMCPMC5411079
OpenAlexW2600732972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.