Evidence map›Paper›PMID 28355560›Full record

ArticleCell reports2017

Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.

Shaunak Deota, Tandrika Chattopadhyay, Deepti Ramachandran, Eric Armstrong, Beatriz Camacho, Babukrishna Maniyadath, Amit Fulzele, Anne Gonzalez-de-Peredo, John M Denu, Ullas Kolthur-Seetharam

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. SIRT1 Exon 2-Encoded IDR Gates CREB-Dependent Transcriptional Timing During Fasting.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
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  4. Article
  5. Review
  6. Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Shaunak DeotaDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Tandrika ChattopadhyayDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Deepti RamachandranDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Eric ArmstrongWisconsin Institute for Discovery and Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, UW-Madison, Madison, WI 53715, USA.
Beatriz CamachoWisconsin Institute for Discovery and Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, UW-Madison, Madison, WI 53715, USA.
Babukrishna ManiyadathDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Amit FulzeleInstitut de Pharmacologie et de Biologie Structurale (IPBS), CNRS - UMR 5089, Toulouse 31077, France.
Anne Gonzalez-de-PeredoInstitut de Pharmacologie et de Biologie Structurale (IPBS), CNRS - UMR 5089, Toulouse 31077, France.
John M DenuWisconsin Institute for Discovery and Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, UW-Madison, Madison, WI 53715, USA.
Ullas Kolthur-SeetharamDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India. Electronic address: ullas@tifr.res.in.
Tata Institute of Fundamental Research · INUniversity of Wisconsin–Madison · USCentre National de la Recherche Scientifique · FR

Funding

Reversible protein acetylation and sirtuin functionR01GM065386 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI DENU, JOHN M · 2003 to 2022
$7.3M
NIGMS NIH HHS R01 GM065386
6 · The paper itself

Abstract

The conserved NAD

Indexed as

Organ SpecificityAnimalsBiocatalysisCattleConserved SequenceEvolution, MolecularExonsFatty AcidsGene Expression RegulationMiceMutant ProteinsOxidation-ReductionProtein BindingProtein DomainsProtein IsoformsProtein MultimerizationFatty AcidsMutant ProteinsProtein IsoformsSirtuin 1Tumor Suppressor Protein p53AKTDNA damageE2insulin signalingisoformp53PGC1αPPARαSIRT1SIRT1-Δspecificity domainβ-oxidation

Identifiers

PMID28355560
PMCPMC5545126
OpenAlexW2604022569

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.