Evidence map›Paper›PMID 28355546›Full record

ArticleBiophysical journal2017

Gramicidin A Channel Formation Induces Local Lipid Redistribution I: Experiment and Simulation.

Andrew H Beaven, Andreia M Maer, Alexander J Sodt, Huan Rui, Richard W Pastor, Olaf S Andersen, Wonpil Im

Abstract read
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Hydrophobic mismatch induces lipid sorting based on tail unsaturation.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Electromechanically induced membrane restructuring enables learning and memory.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. P-type ATPase magnesium transporter MgtA acts as a dimer.Nature structural & molecular biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. CHARMM-GUIJournal of chemical theory and computation · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Mechanisms underlying drug-mediated regulation of membrane protein function.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew H BeavenDepartment of Chemistry, The University of Kansas, Lawrence, Kansas.
Andreia M MaerDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York.
Alexander J SodtEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Huan RuiDepartment of Biological Sciences and Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania.
Richard W PastorLaboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Olaf S AndersenDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York. Electronic address: sparre@med.cornell.edu.
Wonpil ImDepartment of Biological Sciences and Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania. Electronic address: wonpil@lehigh.edu.

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI NAKAMOTO, ROBERT K. · 2010 to 2017
$31.9M
Computer Simulations of Membranes and BiopolymersZIAHL000340 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI PASTOR, RICHARD WALTER · 2009 to 2025
$29.1M
TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAEDER, JAMES · 2012 to 2021
$16.3M
Energetics of Channel-Bilayer InteractionsR01GM021342 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANDERSEN, OLAF S. · 1985 to 2021
$9.9M
Molecular simulations of lipid curvature stress and its effect on transmembrane proteinsZIAHD008955 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SODT, ALEXANDER · 2016 to 2025
$6.2M
NIGMS NIH HHS P41 GM103712NIGMS NIH HHS R01 GM021342NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

Integral membrane protein function can be modulated by the host bilayer. Because biological membranes are diverse and nonuniform, we explore the consequences of lipid diversity using gramicidin A channels embedded in phosphatidylcholine (PC) bilayers composed of equimolar mixtures of di-oleoyl-PC and di-erucoyl-PC (dC

Indexed as

Models, MolecularElasticityGramicidinHydrophobic and Hydrophilic InteractionsLipid BilayersProtein Structure, SecondaryGramicidinLipid Bilayers

Identifiers

PMID28355546
PMCPMC5375002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.