ArticleBiochemistry2017
Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.
Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- A molecular basis of Ferredoxin Reductase (FdxR) mutations that result in mitochondriopathies.Journal of inorganic biochemistry · 2025Article
- Optimization of CYP27A1 recombinant protein expression.Protein expression and purification · 2025Article
- Identification and functional characterization of compound heterozygous CYP11B1 gene mutations.Endocrine · 2024Article
- Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail.Journal of inorganic biochemistry · 2023Article
- Selectivity of osilodrostat as an inhibitor of human steroidogenic cytochromes P450.The Journal of steroid biochemistry and molecular biology · 2023Article
- Congenital adrenal hyperplasia caused by compound heterozygosity of two novel CYP11B1 gene variants.Hormones (Athens, Greece) · 2022Review
- Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding.Biochemistry · 2022Article
- Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin.Archives of biochemistry and biophysics · 2021Article
- Functional interactions of adrenodoxin with several human mitochondrial cytochrome P450 enzymes.Archives of biochemistry and biophysics · 2020Article
- Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1.Biochemistry · 2020Article
- Specificity of the Redox Complex between Cytochrome P450 24A1 and Adrenodoxin Relies on Carbon-25 Hydroxylation of Vitamin-D Substrate.Drug metabolism and disposition: the biological fate of chemicals · 2019Article
- Catalytic modulation of human cytochromes P450 17A1 and P450 11B2 by phospholipid.The Journal of steroid biochemistry and molecular biology · 2018Article
- The cytochrome P450 24A1 interaction with adrenodoxin relies on multiple recognition sites that vary among species.The Journal of biological chemistry · 2018Article
- Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.The Journal of biological chemistryArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mitochondrial cytochromes P450 11B1 and P450 11B2 are responsible for the final stages of cortisol and aldosterone synthesis, respectively. Dysregulation of both enzymes has been implicated in secondary forms of hypertension. Molecular recognition of the cytochromes P450 with their corresponding redox partner is a key step in the catalytic cycle, yet the precise nature of the interaction of P450 11B1 or P450 11B2 with their proximal partner, adrenodoxin (Adx), is still unknown. Here, we obtained P450 11B1·Adx
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