Trial reportClinics (Sao Paulo, Brazil)2017
Controlled clinical trial addressing teeth whitening with hydrogen peroxide in adolescents: a 12-month follow-up.
Trial report in Clinics (Sao Paulo, Brazil), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01998386 (Tooth Whitening With Hydrogenperoxide in Adolescents - Controlled Clinical Trial), which is not on this map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tooth Whitening With Hydrogenperoxide in Adolescents - Controlled Clinical Trial
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Protective role of calcium-based agents in dental bleaching gels: insights from a systematic review and meta-analysis of clinical and laboratory evidence.Clinical oral investigations · 2025Pooled it
- Assessment of color changes and adverse effects of over-the-counter bleaching protocols: a systematic review and network meta-analysis.Clinical oral investigations · 2024Pooled it
- Prognosis in home dental bleaching: a systematic review.Clinical oral investigations · 2023Pooled it
- Home-based chemically-induced whitening (bleaching) of teeth in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Efficacy and safety of low-concentration whitestrips for extrinsic tooth discoloration: a randomized controlled trial.Frontiers in oral health · 2026Trial
- In-office dental bleaching in adolescents using 6% hydrogen peroxide with and without gingival barrier: a randomized double-blind clinical trial.Journal of applied oral science : revista FOB · 2024Trial
- In-office dental bleaching in adolescents using 6% hydrogen peroxide with different application tips: randomized clinical trial.Journal of applied oral science : revista FOB · 2023Trial
- Gingival irritation in patients submitted to at-home bleaching with different cutouts of the bleaching tray: a randomized, single-blind clinical trial.Clinical oral investigations · 2022Trial
- Evaluation of the genotoxic potential of different delivery methods of at-home bleaching gels: a single-blind, randomized clinical trial.Clinical oral investigations · 2019Trial
- Effects of popular Saudi Arabian beverages on tooth shade after home bleaching: an in vitro analysis.BMC oral health · 2025Article
- Evaluation of the Effectiveness of Different Types of Professional Tooth Whitening: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Effectiveness of KTP lasers in tooth bleaching, by comparing tooth color change after bleaching with KTP, Nd:YAG, Er:YAG, and diode laser system: A systematic review.Journal of conservative dentistry and endodontics · 2024Review
- Titanium dioxide nanotubes in a hydrogen peroxide-based bleaching agent: physicochemical properties and effectiveness of dental bleaching under the influence of a poliwave led light activation.Clinical oral investigations · 2023Article
- Is it time to reconsider the use of vital teeth bleaching in children and adolescents in Europe?European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Article
- Hydrogen peroxide penetration into the pulp chamber during conventional in-office bleaching and diode laser-assisted bleaching with three different wavelengths.Laser therapy · 2019Article
- Evaluation of in-office tooth whitening treatment with violet LED: protocol for a randomised controlled clinical trial.BMJ open · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectives: To evaluate the colorimetric change in incisors and canines of adolescents aged 12 to 20 years submitted to at-home whitening and to evaluate satisfaction, sensitivity and discomfort during the procedures through a questionnaire.
method: Thirty adolescents were randomly assigned to the following groups: 1) 6.0% hydrogen peroxide (White Class with calcium - FGM); 2) 7.5% hydrogen peroxide (White Class with calcium - FGM); 3) 10% hydrogen peroxide (Oral B 3D White - Oral-B); 4) Control group - placebo. Assessments were performed prior to treatment as well as at 7, 30, 180 and 360 days after treatment. Friedman's ANOVA was used to analyze color. The Kruskal-Wallis test followed by Dunn's post hoc test was used to compare the groups at the different evaluation times. Answers on the questionnaires were ranked, and non-parametrical tests were employed. The groups were compared in each period using the Kruskal-Wallis test followed by the Student-Newman-Keuls test. Categorical data were analyzed using Fisher's exact test, and the Wilcoxon test was used for the analysis of different periods. P-values were corrected using the Hyan-Holm step-down Bonferroni procedure. Clinicaltrials.gov: NCT01998386.
results: Similar results were obtained one month after treatment with both tooth whitening gels and whitening strips. Patients were partially satisfied with the treatment after the first and second weeks and would recommend it. All products demonstrated color stability after 12 months of follow-up.
conclusions: The bleaching procedure was efficient, and the patients could perceive its result. Further investigations are needed to determine the effects of bleaching on young teeth.
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