ArticlePloS one2017
Epidemiology and outcomes of hypoglycemia in patients with advanced diabetic kidney disease on dialysis: A national cohort study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Predictive Models for Hypoglycemia Risk in Haemodialysis Patients With Diabetic Kidney Disease: Systematic Review and Meta-Analysis.Journal of clinical nursing · 2026Pooled it
- Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes.PloS one · 2018 · on this mapTrial
- Role of automated insulin delivery (AID) systems in glucose control in patients with diabetes mellitus undergoing dialysis in Calabria: AID-DIAL-CAL.Acta diabetologica · 2026Article
- Blood Glucose Management Behaviour Among Haemodialysis Patients with Diabetes: A Qualitative Study Guided by the Theory of Planned Behaviour.Patient preference and adherence · 2026Article
- Frequent hypoglycemia during hemodialysis in ESRD patients leads to higher risk of death.Renal failure · 2025Article
- Unraveling hypoglycemia risk during hemodialysis: a predictive model from a nested case-control study.Frontiers in physiology · 2025Article
- Healthcare utilization, mortality, and cardiovascular events following GLP1-RA initiation in chronic kidney disease.Nature communications · 2024Article
- Development and validation of a prediction model for self-reported hypoglycemia risk in patients with type 2 diabetes: A longitudinal cohort study.Journal of diabetes investigation · 2024Article
- Burden of impaired awareness of hypoglycemia in people with diabetes undergoing hemodialysis.BMJ open diabetes research & care · 2024Article
- Development of a clinical automatic calculation of hypoglycemia during hemodialysis risk in patients with diabetic nephropathy.Diabetology & metabolic syndrome · 2023Article
- Adapted Diabetes Complications Severity Index and Charlson Comorbidity Index in predicting all-cause and cause-specific mortality among patients with type 2 diabetes.BMJ open diabetes research & care · 2023Article
- Risk for hypoglycemic emergency with levofloxacin use, a population-based propensity score matched nested case-control study.PloS one · 2022Article
- Diabetes mellitus in dialysis and renal transplantation.Therapeutic advances in endocrinology and metabolism · 2021Review
- Article
- Glycemic Monitoring and Management in Advanced Chronic Kidney Disease.Endocrine reviews · 2020Review
- Relationships of diabetes self-care behaviours to glycaemic control in adults with type 2 diabetes and comorbid heart failure.Nursing open · 2020Article
- Predisposing factors for hypoglycaemia in the emergency department.The Journal of international medical research · 2019Article
- Effects of sarpogrelate on microvascular complications with type 2 diabetes.International journal of clinical pharmacy · 2019Observational
- Protective Effects of Kaempferitrin on Advanced Glycation End Products Induce Mesangial Cell Apoptosis and Oxidative Stress.International journal of molecular sciences · 2018Article
- Diabetic Kidney Disease: Is There a Role for Glycemic Variability?Current diabetes reports · 2018Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with advanced diabetic kidney disease (DKD) behave differently to diabetic patients without kidney disease. We aimed to investigate the associations of hypoglycemia and outcomes after initiation of dialysis in patients with advanced DKD on dialysis.
methodsUsing National Health Insurance Research Database, 20,845 advanced DKD patients beginning long-term dialysis between 2002 and 2006 were enrolled. We investigated the incidence of severe hypoglycemia episodes before initiation of dialysis. Patients were followed from date of first dialysis to death, end of dialysis, or 2008. Main outcomes measured were all-cause mortality, myocardial infarction (MI), and subsequent severe hypoglycemic episodes after dialysis.
results19.18% patients had at least one hypoglycemia episode during 1-year period before initiation of dialysis. Advanced DKD patients with higher adapted Diabetes Complications Severity Index (aDCSI) scores were associated with more frequent hypoglycemia (P for trend < 0.001). Mortality and subsequent severe hypoglycemia after dialysis both increased with number of hypoglycemic episodes. Compared to those who had no hypoglycemic episodes, those who had one had a 15% higher risk of death and a 2.3-fold higher risk of subsequent severe hypoglycemia. Those with two or more episodes had a 19% higher risk of death and a 3.9-fold higher risk of subsequent severe hypoglycemia. However, previous severe hypoglycemia was not correlated with risk of MI after dialysis.
conclusionsThe rate of severe hypoglycemia was high in advanced DKD patients. Patients with higher aDCSI scores tended to have more hypoglycemic episodes. Hypoglycemic episodes were associated with subsequent hypoglycemia and mortality after initiation of dialysis. We studied the associations and further study is needed to establish cause. In addition, more attention is needed for hypoglycemia prevention in advanced DKD patients, especially for those at risk patients.
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