Evidence map›Paper›PMID 28355204›Full record

ArticlePediatric research2017

Characterization of CD31 expression on murine and human neonatal T lymphocytes during development and activation.

Adam J Fike, Linda T Nguyen, Ogan K Kumova, Alison J Carey

Open access · bronzeAbstract read
In one paragraph

Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Age-Dependent Differences in T-Cell Responses to Influenza A Virus.American journal of respiratory cell and molecular biology · 2020
    Review
  5. Review
  6. Dissecting the defects in the neonatal CD8Journal of leukocyte biology · 2019
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Adam J FikeDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Linda T NguyenDepartment of Pediatrics, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Ogan K KumovaDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Alison J CareyDepartments of Microbiology and Immunology and Pediatrics, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Drexel University · US

Funding

Investigation of Neonatal Influenza PathogenesisK08AI108791 · NIAID · DREXEL UNIVERSITY · PI CAREY, ALISON J · 2014 to 2018
$886k
NIAID NIH HHS K08 AI108791
6 · The paper itself

Abstract

BackgroundCD31, expressed by the majority of the neonatal T-cell pool, is involved in modulation of T-cell receptor signaling by increasing the threshold for T-cell activation. Therefore, CD31 could modulate neonatal tolerance and adaptive immune responses.MethodsLymphocytes were harvested from murine neonates at different ages, human late preterm and term cord blood, and adult peripheral blood. Human samples were activated over a 5-day period to simulate acute inflammation. Mice were infected with influenza; lungs and spleens were harvested at days 6 and 9 post infection and analyzed by flow cytometry.ResultsCD31-expressing neonatal murine CD4

Indexed as

AnimalsFetal BloodFlow CytometryHumansImmune SystemInfant, PrematureLungLymphocyte ActivationMiceMice, Inbred C57BLOrthomyxoviridae InfectionsPlatelet Endothelial Cell Adhesion Molecule-1Signal TransductionTime FactorsT-LymphocytesPlatelet Endothelial Cell Adhesion Molecule-1

Identifiers

PMID28355204
PMCPMC5509503
OpenAlexW2598721814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.