Evidence map›Paper›PMID 28355182›Full record

ArticleNature2017

Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP.

Dick Wu, Taulant Bacaj, Wade Morishita, Debanjan Goswami, Kristin L Arendt, Wei Xu, Lu Chen, Robert C Malenka, Thomas C Südhof

Open access · greenAbstract read
In one paragraph

Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 192 citations in OpenAlex.

  1. Article
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  17. Neurotransmitter release is triggered by a calcium-induced rearrangement in the Synaptotagmin-1/SNARE complex primary interface.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Article
  20. Activity-dependent diffusion trapping of AMPA receptors as a key step for expression of early LTP.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dick WuDepartment of Molecular &Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA.
Taulant BacajDepartment of Molecular &Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA.
Wade MorishitaNancy Pritzker Laboratory, Stanford University Medical School, Stanford, California 94305, USA.
Debanjan GoswamiNancy Pritzker Laboratory, Stanford University Medical School, Stanford, California 94305, USA.
Kristin L ArendtDepartment of Neurosurgery, Stanford University Medical School, Stanford, California 94305, USA.
Wei XuDepartment of Molecular &Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA.
Lu ChenDepartment of Neurosurgery, Stanford University Medical School, Stanford, California 94305, USA.
Robert C MalenkaNancy Pritzker Laboratory, Stanford University Medical School, Stanford, California 94305, USA.
Thomas C SüdhofDepartment of Molecular &Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA.
Stanford University · USHoward Hughes Medical Institute · US

Funding

Role of synaptotagmins and neurexin ligands in homeostatic synaptic plasticityP50MH086403 · NIMH · STANFORD UNIVERSITY · PI SUDHOF, THOMAS C. · 2009 to 2019
$18.4M
Developmental Pathophysiology of Synapses in a Mouse Model of Fragile X SyndromeR01HD084215 · NICHD · STANFORD UNIVERSITY · PI CHEN, LU · 2014 to 2018
$3.3M
Large-Scale Molecular Interrogation of Synaptic TransmissionR01NS077906 · NINDS · STANFORD UNIVERSITY · PI CHEN, LU, MALENKA, ROBERT C · 2011 to 2014
$2.5M
Regulation of synaptic transmission by retinoic acid signalingR01MH091193 · NIMH · STANFORD UNIVERSITY · PI CHEN, LU · 2011 to 2015
$2.3M
Asynchronous Release in Synaptic TransmissionK99MH107618 · NIMH · STANFORD UNIVERSITY · PI WU, DI · 2015 to 2016
$245k
Role of Synaptotagmins in Synaptic Plasticity in the HippocampusF32MH100752 · NIMH · STANFORD UNIVERSITY · PI WU, DI · 2013 to 2015
$90k
NIMH NIH HHS F32 MH100752NIMH NIH HHS K99 MH107618NIMH NIH HHS P50 MH086403NIMH NIH HHS R01 MH091193NINDS NIH HHS R01 NS077906
6 · The paper itself

Abstract

Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory. During the induction of NMDA-receptor-dependent LTP, Ca

Indexed as

ExocytosisAnimalsCA1 Region, HippocampalCalciumFemaleLong-Term PotentiationMaleMiceMutationProtein TransportPyramidal CellsReceptors, AMPASynapsesSynaptic TransmissionSynaptotagminsCalciumReceptors, AMPASynaptotagmins

Identifiers

PMID28355182
PMCPMC5734942
OpenAlexW2600293296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.