Evidence map›Paper›PMID 28355059›Full record

ReviewACS chemical biology2017

Membrane Oxidation in Cell Delivery and Cell Killing Applications.

Ting-Yi Wang, M Daben J Libardo, Alfredo M Angeles-Boza, Jean-Philippe Pellois

Abstract readReview
In one paragraph

Review in ACS chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Article
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  5. Review
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  7. Article
  8. Bacterial responses toRSC advances · 2025
    Article
  9. Article
  10. Light-driven self-sterilizing cotton fabric and drug delivery: improvement of the antimicrobial activity of 4-sulfo-1,8-naphthalimide via its dendrimer and metallic dendrimer formation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Curvature-Assisted Vesicle Explosion Under Light-Induced Asymmetric Oxidation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  15. Article
  16. Review
  17. Review
  18. Effect of Functional Nanoporous TiOInternational journal of molecular sciences · 2023
    Article
  19. Antioxidant Status and Biotechnological Potential of NewAntioxidants (Basel, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ting-Yi WangDepartment of Biochemistry and Biophysics, Texas A&M University , College Station, Texas 77843, United States.
M Daben J LibardoDepartment of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States.
Alfredo M Angeles-BozaDepartment of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States.ORCID 0000-0002-5560-4405
Jean-Philippe PelloisDepartment of Biochemistry and Biophysics, Texas A&M University , College Station, Texas 77843, United States.ORCID 0000-0001-5536-925X

Funding

Mechanisms and optimization of endosomal escape for delivery applicationsR01GM110137 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI PELLOIS, JEAN-PHILIPPE · 2015 to 2022
$2.3M
NIGMS NIH HHS R01 GM110137
6 · The paper itself

Abstract

Cell delivery or cell killing processes often involve the crossing or disruption of cellular membranes. We review how, by modifying the composition and properties of membranes, membrane oxidation can be exploited to enhance the delivery of macromolecular cargoes into live human cells. We also describe how membrane oxidation can be utilized to achieve efficient killing of bacteria by antimicrobial peptides. Finally, we present recent evidence highlighting how membrane oxidation is intimately engaged in natural biological processes such as antigen delivery in dendritic cells and in the killing of bacteria by antimicrobial peptides. Overall, the insights that have been recently gained in this area should facilitate the development of more effective delivery technologies and antimicrobial therapeutic approaches.

Indexed as

AntigensAntimicrobial Cationic PeptidesBacteriaCell DeathCell MembraneCell Membrane PermeabilityDendritic CellsDrug Delivery SystemsHumansOxidation-ReductionAntigensAntimicrobial Cationic Peptides

Identifiers

PMID28355059
PMCPMC5905413

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.