ArticleJournal of virology1988
Structural and functional domains of the myb oncogene: requirements for nuclear transport, myeloid transformation, and colony formation.
Article in Journal of virology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Review
- v-Myb represses the transcription of Ets-2.Oncogene · 2007Article
- Transformation by v-Myb.Oncogene · 1999Review
- Overexpression of an alternatively spliced form of c-Myb results in increases in transactivation and transforms avian myelomonoblasts.Journal of virology · 1998Article
- Cells transformed by a v-Myb-estrogen receptor fusion differentiate into multinucleated giant cells.Journal of virology · 1997Article
- FAETL motif required for leukemic transformation by v-Myb.Journal of virology · 1996Article
- Cloning and initial characterization of 14 myb-related cDNAs from tomato (Lycopersicon esculentum cv. Ailsa Craig).Plant molecular biology · 1996Article
- Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Journal of virology · 1995Article
- The carboxyterminus of human c-myb protein stimulates activated transcription in trans.Nucleic acids research · 1994Article
- Transformation of myelomonocytic cells by the avian myeloblastosis virus is determined by the v-myb oncogene, not by the unique long terminal repeats of the virus.Journal of virology · 1994Article
- Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo.Molecular and cellular biology · 1993Article
- Individual repeats of Drosophila Myb can function in transformation by v-Myb.Journal of virology · 1993Article
- Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae.Molecular and cellular biology · 1993Article
- Only the DNA binding and transactivation domains of c-Myb are required to block terminal differentiation of murine erythroleukemia cells.Molecular and cellular biology · 1993Article
- Mechanism of c-myc regulation by c-Myb in different cell lineages.Molecular and cellular biology · 1993Article
- Influence of the v-Myb transactivation domain on the oncoprotein's transformation specificity.The EMBO journal · 1993Article
- Reduction of a conserved Cys is essential for Myb DNA-binding.Nucleic acids research · 1992Article
- Expression of the CD4 gene requires a Myb transcription factor.Molecular and cellular biology · 1992Article
- The cellular oncogene c-myb can interact synergistically with the Epstein-Barr virus BZLF1 transactivator in lymphoid cells.Molecular and cellular biology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The v-myb oncogene of avian myeloblastosis virus causes acute myelomonocytic leukemia in vivo and transforms only myeloid cells in vitro. Its product, p48v-myb, is a nuclear protein of unknown function. To determine structure-function relationships for this protein, we constructed a series of deletion mutants of v-myb, expressed them in retroviral vectors, and studied their biochemical and biological properties. We used these mutants to identify two separate domains of p48v-myb which had distinct roles in its accumulation in the cell nucleus. We showed that the viral sequences which normally encode both termini of p48v-myb were dispensible for transformation. In contrast, both copies of the highly conserved v-myb amino-terminal repeat were required for transformation. We also identified a carboxyl-terminal domain of p48v-myb which was required for the growth of v-myb-transformed myeloblasts in soft agar but not for morphological transformation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.