ReviewAntioxidants (Basel, Switzerland)2017
Zinc and Oxidative Stress: Current Mechanisms.
Review in Antioxidants (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
261 citing papers in PubMed, 3 syntheses or guidelines pooled it, 621 citations in OpenAlex.
- Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Antioxidant supplementation for sickle cell disease.The Cochrane database of systematic reviews · 2024Pooled it
- The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases.International journal of molecular sciences · 2023Pooled it
- Trial
- Effect of novel trace elements on liver and kidney functions, immunity, antioxidant indices and caecal microbiota of growing rabbits.Veterinary and animal science · 2026Article
- SLC30A8 (ZnT8) at the crossroads of epigenetics and microRNA regulation in type 2 diabetes and nephropathy.World journal of nephrology · 2026Review
- Targeting Reactive Species Stress and Nutrient Sensing to Enhance NK-Cell Function: Mechanistic Strategies for Overcoming Pancreatic Cancer Progression and Resistance Through Supplement Therapy.International journal of molecular sciences · 2026Review
- Zinc alleviates arsenic-induced muscle injury in common carp through modulation of oxidative stress and related signaling pathways.Fish physiology and biochemistry · 2026Article
- A Narrative Review of Zinc Deficiency-Associated Anemia.Hematology reports · 2026Review
- Biological and mechanistic effects of selenium and zinc in coronary artery bypass surgery: preoperative and postoperative evaluation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Effects of zinc oxide nano particles on morphine withdrawal syndrome in mice (insights to the postpartum depression, reflexive motor behaviors and antioxidant activity).Scientific reports · 2026Article
- Enhancement of Morpho-Physiological, Physiological, and Antioxidant Capacity of Saffron (Food science & nutrition · 2026Article
- Unraveling the Impact of Serum Zinc Levels on Chronic Kidney Disease: Machine Learning and SHAP Value Interpretation.Food science & nutrition · 2026Article
- The Dual Role of Zinc Homeostasis in Gram-Negative Bacterial Pathogenicity and Host Immune Defense.Microorganisms · 2026Review
- Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction.Cell reports. Medicine · 2026Article
- Serum Macro- and Trace-Element Alterations and Redox Imbalance in Cattle with Naturally Occurring Dermatophytosis.Animals : an open access journal from MDPI · 2026Article
- Serum Zinc Levels in Early Life and Risk of Elevated Carotid Intima-Media Thickness: An 8-Year Prospective Study.Cardiovascular toxicology · 2026Article
- Dietary L-Arginine and Zinc Oxide Nanoparticles Improve Growth Performance, Oxidative Status, Immunity, and Intestinal Integrity Indicators in Heat-Stressed Weaned Rabbits.Veterinary sciences · 2026Article
- Effect of zinc oxide nanoparticle supplementation in Santa Inês ewes during the transition period.Tropical animal health and production · 2026Article
- Higher dietary antioxidant quality is linked to reduced diabetic nephropathy risk in type 2 diabetes: a case-control study.Scientific reports · 2026Article
201 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules, contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress. Zinc acts as a co-factor for important enzymes involved in the proper functioning of the antioxidant defense system. In addition, zinc protects cells against oxidative damage, acts in the stabilization of membranes and inhibits the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH-Oxidase). Zinc also induces the synthesis of metallothioneins, which are proteins effective in reducing hydroxyl radicals and sequestering reactive oxygen species (ROS) produced in stressful situations, such as in type 2 diabetes, obesity and cancer. Literature provides strong evidence for the role of zinc in the protection against oxidative stress in several diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.