ArticleMarine drugs2017
Another Look at Pyrroloiminoquinone Alkaloids-Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues.
Open access · goldAbstract read
In one paragraph
Article in Marine drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Semisynthesis of Mycothiazole Analogs having Distinct Bioactivity.ACS medicinal chemistry letters · 2026Article
- Optimized Biomimetic Syntheses of Discorhabdin B and Aleutianamine Drives a Deeper Exploration of Their Anticancer Potential.Journal of the American Chemical Society · 2026Article
- On the Discorhabdins Leading to the Aleutianamine Ring System: A One-Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology.Angewandte Chemie (International ed. in English) · 2026Article
- Aleutianamine B, A Novel Chiral Sulfoxide Isolated fromJournal of natural products · 2026Article
- A Divergent Synthesis of Numerous Pyrroloiminoquinone Alkaloids Identifies Promising Antiprotozoal Agents.Journal of the American Chemical Society · 2024Article
- Unexpected Transformations during Pyrroloiminoquinone Biosynthesis.Journal of the American Chemical Society · 2024Article
- Unified Synthesis and Biological Evaluation of Makaluvamine J and Its Analogs.Molecules (Basel, Switzerland) · 2024Article
- Current Perspectives on Pyrroloiminoquinones: Distribution, Biosynthesis and Drug Discovery Potential.Molecules (Basel, Switzerland) · 2022Review
- Therapeutic potential of pyrrole and pyrrolidine analogs: an update.Molecular diversity · 2022Review
- Phytochemical analysis and comprehensive evaluation of pharmacological potential ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives.Molecules (Basel, Switzerland) · 2022Review
- Structure-Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges.Revista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia · 2022Review
- Effects of Sponge-Derived Alkaloids on Activities of the Bacterial α-D-Galactosidase and Human Cancer Cell α-N-Acetylgalactosaminidase.Biomedicines · 2021Article
- Unlocking the Diversity of Pyrroloiminoquinones Produced by Latrunculid Sponge Species.Marine drugs · 2021Article
- RETRACTED: Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells.Molecules (Basel, Switzerland) · 2020Article
- Computationally Assisted Discovery and Assignment of a Highly Strained and PANC-1 Selective Alkaloid from Alaska's Deep Ocean.Journal of the American Chemical Society · 2019Article
- Molecular Networking Reveals Two Distinct Chemotypes in Pyrroloiminoquinone-Producing Tsitsikamma favus Sponges.Marine drugs · 2019Article
- The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells.Tetrahedron · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Sheng LinDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. linsheng2014cn@gmail.com.
Erin P McCauleyDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. emccaule@ucsc.edu.
Nicholas Lorig-RoachDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. nlorigro@ucsc.edu.
Karen TenneyDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. ktenney@ucsc.edu.
Cassandra N NaphenDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. cnaphen@gmail.com.
Ai-Mei YangDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. aimeiyang@163.com.
Tyler A JohnsonDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. tyler.johnson@dominican.edu.
Thalia HernadezDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. taj_@chemistry.ucsc.edu.
Ramandeep RattanDepartment of Internal Medicine, Division of Hematology and Oncology, Henry Ford Hospital, Detroit, MI 48202, USA. rrattan1@hfhs.org.
Frederick A ValerioteDepartment of Internal Medicine, Division of Hematology and Oncology, Henry Ford Hospital, Detroit, MI 48202, USA. FVALERI1@hfhs.org.
Phillip CrewsDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. pcrews@ucsc.edu.
University of California, Santa Cruz · USHenry Ford Hospital · US
Funding
NOVEL CYTOTOXIC NATURAL PRODUCTS FROM MARINE SPONGESR01CA047135 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CREWS, PHIL, VALERIOTE, FREDERICK AUGUSTUS · 1989 to 2017
$8.1MBaccalaureate Bridge to the Biomedical Sciences Program (ACCESS)R25GM051765 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CAMARA, JASON N., CREWS, PHIL · 1994 to 2023
$5.6M800 MHz NMR Spectrometer and Helium CryoprobeS10OD018455 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2015 to 2015
$2.0MNCI NIH HHS R01 CA047135NIGMS NIH HHS R25 GM051765NIH HHS S10 OD018455
Abstract
This study began with the goal of identifying constituents from
Indexed as
AlkaloidsAnimalsCell Line, TumorHumansMagnetic Resonance SpectroscopyPoriferaPyrroloiminoquinonesSpectrometry, Mass, Electrospray IonizationStructure-Activity RelationshipAlkaloidsPyrroloiminoquinonesmakaluvaminemarine spongeMS-MS fragmentation profilingPANC-1 and OVCAR-5 cytotoxicityZyzzya fuliginosa
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.