ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2017
Tetanus in adults: results of the multicenter ID-IRI study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Two decades of global research on tetanus vaccines and tetanus immunoglobulins: a comprehensive bibliometric analysis and integrative review (2000-2025).Frontiers in cellular and infection microbiology · 2026Pooled it
- Mortality and risk factors in hospitalised adult patients with tetanus: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Tetanus - a lethal and neglected infectious disease.Annals of medicine and surgery (2012) · 2025Article
- Risk assessment of severe adult tetanus using the NLR and AST level and construction of a nomogram prediction model.Heliyon · 2024Article
- Trends and Hospitalization Outcomes of Tetanus Cases: A Multicenter Retrospective Study in Suzhou, 2013-2023.Risk management and healthcare policy · 2024Article
- C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.Diseases (Basel, Switzerland) · 2023Review
- Assessment of tetanus revaccination regimens in horses not vaccinated in the previous year.The Journal of veterinary medical science · 2023Article
- 6084 Cases of Adult Tetanus from China: A Literature Analysis.Infection and drug resistance · 2023Article
- Tetanus: A disease not to be forgotten.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Successful management of generalized tetanus in a 12-year old girl without anti-tetanus immunoglobulins: a case report.Oxford medical case reports · 2022Article
- Tetanus in Uganda: Clinical Outcomes of Adult Patients Hospitalized at a Tertiary Health Facility Between 2011 and 2020.Open forum infectious diseases · 2022Article
- Factors associated with in-hospital mortality of adult tetanus patients-a multicenter study from Bangladesh.PLoS neglected tropical diseases · 2022Observational
- Survival in canine tetanus - retrospective analysis of 42 cases (2006-2020).Frontiers in veterinary science · 2022Article
- The management of tetanus in adults in an intensive care unit in Southern Vietnam.Wellcome open research · 2021Article
- Admission of tetanus patients to the ICU: a retrospective multicentre study.Annals of intensive care · 2017Article
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33 authors at 20 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tetanus is an acute, severe infection caused by a neurotoxin secreting bacterium. Various prognostic factors affecting mortality in tetanus patients have been described in the literature. In this study, we aimed to analyze the factors affecting mortality in hospitalized tetanus patients in a large case series. This retrospective multicenter study pooled data of tetanus patients from 25 medical centers. The hospitals participating in this study were the collaborating centers of the Infectious Diseases International Research Initiative (ID-IRI). Only adult patients over the age of 15 years with tetanus were included. The diagnosis of tetanus was made by the clinicians at the participant centers. Izmir Bozyaka Education and Research Hospital's Review Board approved the study. Prognostic factors were analyzed by using the multivariate regression analysis method. In this study, 117 adult patients with tetanus were included. Of these, 79 (67.5%) patients survived and 38 (32.5%) patients died. Most of the deaths were observed in patients >60 years of age (60.5%). Generalized type of tetanus, presence of pain at the wound area, presence of generalized spasms, leukocytosis, high alanine aminotransferase (ALT) and C-reactive protein (CRP) values on admission, and the use of equine immunoglobulins in the treatment were found to be statistically associated with mortality (p < 0.05 for all). Here, we describe the prognostic factors for mortality in tetanus. Immunization seems to be the most critical point, considering the advanced age of our patients. A combination of laboratory and clinical parameters indicates mortality. Moreover, human immunoglobulins should be preferred over equine sera to increase survival.
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