ArticleJournal of computational neuroscience2017
Mathematical investigation of IP
Article in Journal of computational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Modeling traveling calcium waves in cellular structures.Journal of computational neuroscience · 2025Article
- Synergistic effects of chemical and biochemical fertilization on yield enhancement and oil quality optimization in 'Zard' olive cultivars.Frontiers in plant science · 2025Article
- Cross Talking Calcium, IPCell biochemistry and biophysics · 2024Article
- Investigating the ability of astrocytes to drive neural network synchrony.PLoS computational biology · 2023Article
- CaInternational journal of molecular sciences · 2023Article
- A complete biomechanical model ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Revising Berg-Purcell for finite receptor kinetics.Biophysical journal · 2021Article
- Local and CNS-Wide Astrocyte Intracellular Calcium Signaling AttenuationThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Modeling of Endothelial Calcium Responses within a Microfluidic Generator of Spatio-Temporal ATP and Shear Stress Signals.Micromachines · 2021Article
- Improved tools to study astrocytes.Nature reviews. Neuroscience · 2020Review
- Spatiotemporal model of tripartite synapse with perinodal astrocytic process.Journal of computational neuroscience · 2020Article
- Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System.Frontiers in cellular neuroscience · 2020Review
- Three dimensional coupled reaction-diffusion modeling of calcium and inositol 1,4,5-trisphosphate dynamics in cardiomyocytes.RSC advances · 2019Article
- Receptor recharge time drastically reduces the number of captured particles.PLoS computational biology · 2018Article
- Increased Cytosolic Calcium Contributes to Hydrogen-Rich Water-Promoted Anthocyanin Biosynthesis Under UV-A Irradiation in Radish Sprouts Hypocotyls.Frontiers in plant science · 2018Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Diversity of Evoked Astrocyte CaFrontiers in systems neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We study evoked calcium dynamics in astrocytes, a major cell type in the mammalian brain. Experimental evidence has shown that such dynamics are highly variable between different trials, cells, and cell subcompartments. Here we present a qualitative analysis of a recent mathematical model of astrocyte calcium responses. We show how the major response types are generated in the model as a result of the underlying bifurcation structure. By varying key channel parameters, mimicking blockers used by experimentalists, we manipulate this underlying bifurcation structure and predict how the distributions of responses can change. We find that store-operated calcium channels, plasma membrane bound channels with little activity during calcium transients, have a surprisingly strong effect, underscoring the importance of considering these channels in both experiments and mathematical settings. Variation in the maximum flow in different calcium channels is also shown to determine the range of stable oscillations, as well as set the range of frequencies of the oscillations. Further, by conducting a randomized search through the parameter space and recording the resulting calcium responses, we create a database that can be used by experimentalists to help estimate the underlying channel distribution of their cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.