Evidence map›Paper›PMID 28353156›Full record

ArticleInternational urology and nephrology2017

Restless legs syndrome in maintenance hemodialysis patients: an epidemiologic survey in Hefei.

Jian-Ping Xiao, Gui-Xia Zhang, Lei Chen, Ben-Gui Sun, Hong-Xu Zhang, Li-Hong Chen, Liang Yuan, Li Hao, De-Guang Wang

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In one paragraph

Article in International urology and nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jian-Ping XiaoDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China.
Gui-Xia ZhangDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China.
Lei ChenDepartment of Nephrology, First People's Hospital of Hefei, 390 Huaihe Road, Hefei, Anhui, China.
Ben-Gui SunDepartment of Nephrology, The Second People's Hospital of Hefei, 246 Heping Road, Hefei, Anhui, China.
Hong-Xu ZhangDepartment of Nephrology, The Second People's Hospital of Anhui, 1686 Dangshan Road, Hefei, Anhui, China.
Li-Hong ChenDepartment of Nephrology, The Armed Police Hospital of Anhui, 78 Shangfeng Road, Hefei, Anhui, China.
Liang YuanDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China.
Li HaoDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China.
De-Guang WangDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China. wangdeguang@ahmu.edu.cn.
Anhui Medical University · CNHefei First People's Hospital · CNSecond Hospital of Anhui Medical University · CNThird People's Hospital of Hefei · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the prevalence of restless legs syndrome (RLS) in maintenance hemodialysis (MHD) patients and its possible influencing factors.

methodsMHD patients were consecutively enrolled from five hemodialysis centers in Hefei. Clinical, demographics, and laboratory data were recorded from December 2013 to March 2014. RLS diagnosis scale, Zung Self-Rating Depression Scale (SDS), Zung Self-Rating Anxiety Scale (SAS), Pittsburgh Sleep Quality Index (PSQI), and kidney disease and quality of life (KDQOLTM-36) were used for analysis.

resultsA total of 269 MHD patients (81 women, 188 men) were enrolled, among which 39 patients were diagnosed as RLS. The median duration of dialysis therapy was 33 months and the prevalence of RLS was 14.5%. Compared with RLS-negative patients, RLS-positive patients had lower hemoglobin level (98.67 ± 13.50 vs 106.34 ± 17.75, P = 0.011) and higher alkaline phosphatase concentration [131.0 (98.0, 226.0) vs 94.0 (69.8, 157.5), P = 0.001]. The multivariate logistic regression showed that high hemoglobin level (OR 0.975, 95% CI 0.956-0.995, P = 0.015) was a protective factor for RLS, while high alkaline phosphatase (OR 1.003, 95% CI 1.001-1.005, P = 0.018) was an independent risk factor for RLS. RLS patients had significantly higher PSQI scores (P < 0.001), reduced subjective sleep quality (P < 0.001), increased sleep latency (P < 0.007), shorter sleep duration (P < 0.001), lower sleep efficiency (P = 0.001), higher sleep disturbances (P < 0.001), and increased daytime dysfunction (P = 0.019).

conclusionOur findings demonstrated that the prevalence of RLS was 14.5% in Hefei. High hemoglobin level was a protective factor for RLS, and high alkaline phosphatase was an independent risk factor. RLS affects many aspects of quality of life and sleep quality, which may contribute to the presence of depression and anxiety.

Indexed as

Renal DialysisAdultAgedAlkaline PhosphataseChinaFemaleHemoglobinsHumansMaleMiddle AgedPrevalenceProtective FactorsRenal Insufficiency, ChronicRestless Legs SyndromeRisk FactorsSeverity of Illness IndexAlkaline PhosphataseHemoglobinsAlkaline phosphataseHemoglobinMaintenance hemodialysisPrevalenceRestless legs syndrome

Identifiers

PMID28353156
OpenAlexW2600014976

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.