ArticleEuropean archives of psychiatry and clinical neuroscience2017
The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene.
Article in European archives of psychiatry and clinical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Oxytocin dysfunction in severe mental illnesses following adverse childhood experiences: a systematic review.BMC psychiatry · 2026Pooled it
- A Systematic Review of Candidate Genes for Major Depression.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Main Biological Models of Resilience.Clinical neuropsychiatry · 2024Review
- Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023Review
- The interaction of the oxytocin receptor gene and child abuse subtypes on social cognition in euthymic patients with bipolar disorder type I.Frontiers in psychiatry · 2023Article
- The Interaction Effect of Parental Rejection and Oxytocin Receptor Gene Polymorphism on Depression: A Cross-Cultural Study in Non-Clinical Samples.International journal of environmental research and public health · 2022Article
- Association Between Childhood Maltreatment,Frontiers in psychiatry · 2022Article
- Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents.BMC psychiatry · 2021Article
- Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother-newborn dyads.Translational psychiatry · 2021Article
- Review of eating disorders and oxytocin receptor polymorphisms.Journal of eating disorders · 2021Review
- Decreased Plasma Oxytocin Levels in Patients With PTSD.Frontiers in psychology · 2021Article
- Maternal verbal aggression in early infancy and child's internalizing symptoms: interaction by common oxytocin polymorphisms.European archives of psychiatry and clinical neuroscience · 2020Observational
- The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.The American journal of psychiatry · 2020Review
- Oxytocin receptor gene variants are associated with emotion recognition and resilience, but not with false-belief reasoning performance in healthy young Korean volunteers.CNS neuroscience & therapeutics · 2019Article
- Serotonin Transporter (Frontiers in genetics · 2019Article
- Caring helps: Trait empathy is related to better coping strategies and differs in the poor versus the rich.PloS one · 2019Article
- Stress Response Modulation Underlying the Psychobiology of Resilience.Current psychiatry reports · 2018Review
- Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers.Frontiers in human neuroscience · 2018Article
- No gene-by-environment interaction of BDNFEuropean journal of psychotraumatology · 2018Article
- The Associations Between Oxytocin and Trauma in Humans: A Systematic Review.Frontiers in pharmacology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe oxytocin receptor (OXTR) gene may be involved in resilience or vulnerability towards stress, and hence in the development of stress-related disorders. There are indications that OXTR single nucleotide polymorphisms (SNPs) interact with early life stressors in predicting levels of depression and anxiety. To replicate and extend these findings, we examined whether three literature-based OXTR SNPs (rs2254298, rs53576, rs2268498) interact with childhood maltreatment in the development of clinically diagnosed depression and anxiety disorders.
methodsWe included 2567 individuals from the Netherlands Study of Depression and Anxiety. This sample consisted of 387 healthy controls, 428 people with a current or past depressive disorder, 243 people with a current or past anxiety disorder, and 1509 people with both lifetime depression and anxiety diagnoses. Childhood maltreatment was measured with both an interview and via self-report. Additional questionnaires measured depression and anxiety sensitivity.
resultsChildhood maltreatment was strongly associated with both lifetime depression and anxiety diagnoses, as well as with depression and anxiety sensitivity. However, the OXTR SNPs did not moderate these associations nor had main effects on outcomes.
conclusionsThe three OXTR gene SNPs did not interact with childhood maltreatment in predicting lifetime depression and anxiety diagnoses or sensitivity. This stresses the importance of replication studies with regard to OXTR gene variants in general populations as well as in clearly established clinical samples.
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