Evidence map›Paper›PMID 28353017›Full record

ReviewCurrent hematologic malignancy reports2017

Treatment of Young Adults with Acute Lymphoblastic Leukemia.

Ankit Kansagra, Mark Litzow

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hematologic malignancy reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ankit KansagraMayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Mark LitzowMayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. litzow.mark@mayo.edu.
Mayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Young adults with acute lymphoblastic leukemia are a distinctive category of patients, with substantial difference in disease biology and response to therapy; hence, they pose unique challenges and issues beyond those faced by children and older adults. Despite inferior survival compared to children, there is growing evidence to suggest that young adults have improved outcomes when treated with pediatric-based approaches. With better supportive care and toxicity management and multidisciplinary team and approach, we have made great improvement in outcomes of young adults with ALL. However, despite significant progress, patients with persistence of minimal residual disease have a poor prognosis. This review discusses current controversies in the management of young adults with ALL, outcomes following pediatric and adult protocols, and the role of allogeneic stem cell transplantation. We also explore recent advances in disease monitoring and highlight our approach to incorporation of novel therapies in the management of young adults with ALL.

Indexed as

AdolescentAdultAge FactorsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsAsparaginaseClinical Trials as TopicCombined Modality TherapyDisease ManagementHematopoietic Stem Cell TransplantationHumansImmunotherapyMolecular Targeted TherapyPhiladelphia ChromosomePrecursor Cell Lymphoblastic Leukemia-LymphomaTransplantation, HomologousAntineoplastic AgentsAsparaginaseAdolescent and young adultsAsparaginaseHematopoietic stem cell transplantMonoclonal antibodiesPhiladelphia chromosomeSupportive care

Identifiers

PMID28353017
OpenAlexW2602541652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.