ArticlePharmaceutical research2017
Impact of Micellar Surfactant on Supersaturation and Insight into Solubilization Mechanisms in Supersaturated Solutions of Atazanavir.
Article in Pharmaceutical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Development of Amorphous Solid Dispersion to Improve the Dissolution and Antiproliferative Activity of Brazilin.Drug design, development and therapy · 2026Article
- Development and optimization of a novel spectroscopic method to monitor crystallization behavior of BCS-II drug.Turkish journal of chemistry · 2026Article
- Effect of Surfactants on Posaconazole Crystallization and Polymorphism: Tween 80 vs Span 80.Crystal growth & design · 2025Article
- Article
- Characterizing the Impact of Chitosan on the Nucleation and Crystal Growth of Ritonavir from Supersaturated Solutions.Polymers · 2023Article
- Impact of Surfactants on the Performance of Clopidogrel-Copovidone Amorphous Solid Dispersions: Increased Drug Loading and Stabilization of Nanodroplets.Pharmaceutical research · 2022Article
- Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations.Molecular pharmaceutics · 2021Article
- Triggered Release Enhances the Cytotoxicity of Stable Colloidal Drug Aggregates.ACS chemical biology · 2019Article
- Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses.Pharmaceutics · 2019Article
- Supersaturated polymeric micelles for oral silybin delivery: the role of the Soluplus-PVPVA complex.Acta pharmaceutica Sinica. B · 2019Article
- Crystallization from Supersaturated Solutions: Role of Lecithin and Composite Simulated Intestinal Fluid.Pharmaceutical research · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe goals of this study were to determine: 1) the impact of surfactants on the "amorphous solubility"; 2) the thermodynamic supersaturation in the presence of surfactant micelles; 3) the mechanism of solute solubilization by surfactant micelles in supersaturated solutions.
methodsThe crystalline and amorphous solubility of atazanavir was determined in the presence of varying concentrations of micellar sodium dodecyl sulfate (SDS). Flux measurements, using a side-by-side diffusion cell, were employed to determine the free and micellar-bound drug concentrations. The solubilization mechanism as a function of atazanavir concentration was probed using fluorescence spectroscopy. Pulsed gradient spin-echo proton nuclear magnetic resonance (PGSE-NMR) spectroscopy was used to determine the change in micelle size with a change in drug concentration.
resultsChanges in the micelle/water partition coefficient, K
conclusionsMicellar solubilization of atazanavir is complex, with the solubilization mechanism changing with differences in the degree of (super)saturation. This can result in erroneous predictions of the amorphous solubility and thermodynamic supersaturation in the presence of solubilizing additives. This in turn hinders understanding of the driving force for phase transformations and membrane transport, which is essential to better understand supersaturating dosage forms.
Indexed as
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28352994What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.