Evidence map›Paper›PMID 28352966›Full record

Trial reportNeurocritical care2017

Cold Blooded: Evaluating Brain Temperature by MRI During Surface Cooling of Human Subjects.

Eric J Curran, Daniel L Wolfson, Richard Watts, Kalev Freeman

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurocritical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04973085 (Effect of a Novel Cooling Device on Brain Temperature), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04973085 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of a Novel Cooling Device on Brain Temperature

TypeinterventionalSponsorUniversity of VermontRan2021 to 2022Enrolled22ConditionsHealthyArmsCold circulated water, Body-temperature circulated water
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Eric J CurranDepartment of Surgery, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT, USA.
Daniel L WolfsonDepartment of Surgery, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT, USA.
Richard WattsDepartment of Radiology, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT, USA.
Kalev FreemanDepartment of Surgery, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT, USA. kalev.freeman@uvm.edu.
University of Vermont · USTemple University · US

Funding

Endothelial Ca2+ signals and vasodilatory function after traumatic brain injuryK08GM098795 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FREEMAN, KALEV · 2011 to 2015
$567k
National Institute of General Medical Sciences K08-GM-098795NIGMS NIH HHS K08 GM098795
6 · The paper itself

Abstract

backgroundTargeted temperature management (TTM) confers neurological and survival benefits for post-cardiac arrest patients with return of spontaneous circulation (ROSC) who remain comatose. Specialized equipment for induction of hypothermia is not available in the prehospital setting, and there are no reliable methods for emergency medical services personnel to initiate TTM. We hypothesized that the application of surface cooling elements to the neck will decrease brain temperature and act as initiators of TTM.

methodsMagnetic resonance (MR) spectroscopy was used to evaluate the effect of a carotid surface cooling element on brain temperature in healthy adults.

resultsSix individuals completed this study. We measured a temperature drop of 0.69 ± 0.38 °C (95% CI) in the cortex of the brain following the application of the cooling element. Application of a room temperature element also caused a measurable decrease in brain temperature of 0.66 ± 0.41 °C (95% CI) which may be attributable to baroreceptor activation.

conclusionThe application of surface cooling elements to the neck decreased brain temperature and may serve as a method to initiate TTM in the prehospital setting.

Indexed as

AdultBody TemperatureCerebral CortexCold TemperatureCryotherapyHealthy VolunteersHeart ArrestHumansHypothermia, InducedMagnetic Resonance SpectroscopyNeckOut-of-Hospital Cardiac ArrestCardiac arrestCooling collarMagnetic resonance spectroscopySurface coolingTargeted temperature managementTherapeutic hypothermia

Identifiers

PMID28352966
PMCPMC7293900
OpenAlexW2602322056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.