ReviewOpen medicine (Warsaw, Poland)2015
Risk factors involved in orofacial cleft predisposition - review.
Review in Open medicine (Warsaw, Poland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurodevelopmental disorders in children with cleft lip and palate: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts-A meta-analysis.Birth defects research · 2022Pooled it
- Imaging Characteristics and Differential Diagnosis of Newborn Oral Tumors Based on a Prenatally Diagnosed Neumann Tumor.Diagnostics (Basel, Switzerland) · 2026Article
- Revision Surgery After Complications of Silicone Chin Implants.Journal of clinical medicine · 2026Article
- Epidemiological pattern of cleft lip and palate under Rashtriya Bal Swasthya Karyakram project in the state of Bihar: A cross-sectional hospital-based study.Journal of family medicine and primary care · 2025Article
- Risk Factors for Nonsyndromic Orofacial Clefts Among Saudi Children.Clinical and experimental dental research · 2025Article
- Prenatal exposure to antibiotics and the risk of orofacial clefts: a protocol for a systematic review and meta-analysis.BMJ open · 2024Article
- Orofacial Cleft and Its Association with Consanguineous Marriage and Other Risk Factors: A Case-control Study from a Tertiary Care Hospital in Jammu Province.International journal of clinical pediatric dentistry · 2024Article
- Orofacial Clefts and Maternal Risk Factors: A Population-Based Case-Control Study.Children (Basel, Switzerland) · 2024Article
- Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review.Journal of clinical medicine · 2024Review
- Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study.Archives of craniofacial surgery · 2024Article
- Environmental tobacco smoke exposure and non-syndromic orofacial cleft: Systematic review and meta-analysis.Tobacco induced diseases · 2023Review
- Influence of Domestic Exposure to Polycyclic Aromatic Hydrocarbons on Women's Periconceptional Stage and Associated Risk of Oral Cleft in Offspring.Journal of pharmacy & bioallied sciences · 2022Article
- The characteristics and perioperative outcomes of children with orofacial clefts managed at an academic hospital in Johannesburg, South Africa.BMC pediatrics · 2022Article
- The functional EGF+61 polymorphism and nonsyndromic oral clefts susceptibility in a Brazilian population.Journal of applied oral science : revista FOBArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clefts that occur in children are a special topic. Avoiding risk factors, and also an early diagnosis of cleft possibility can result in minimizing or avoiding them. If on the other hand when clefts occur they require a long-term, multistage specialized treatment. Etiology of clefts seems to be related to many factors. Factors such as genetic, environmental, geographic and even race factors are important. Identification of risk factors can lead to prevention and prophylactic behaviors in order to minimize its occurrence. Exposure to environmental factors at home and work that lead to cleft predisposition should not be disregarded. It seems that before planning a family it would be wise to consult with doctors of different specializations, especially in high-risk families with cleft history in order to analyze previous lifestyle. Clefts are very common in hereditary facial malformations and are causing a lot of other irregularities in the head and neck region. In this paper after a brief papers review authors present socio-geographic, environmental and also work place related factors that are influencing pregnant women condition and should be taken under serious consideration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.