Evidence map›Paper›PMID 28352678›Full record

ArticleOpen medicine (Warsaw, Poland)2015

Correlation between SNPs in CDH1 and gastric cancer in Chinese population.

Yijin Lin, Jintao Yuan, Lihui Wang, Lan Wang, Yunjia Ma, Yuhua Wang, Jianhong Chen, Hong Zhao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open medicine (Warsaw, Poland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yijin LinDanyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
Jintao YuanDanyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
Lihui WangDanyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
Lan WangDanyang Blood Center of Jiangsu Province, Danyang, Jiangsu 212300, China.
Yunjia MaDanyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
Yuhua WangDanyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
Jianhong ChenDanyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
Hong ZhaoDanyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany recent studies revealed that the single nucleotide polymorphisms have considerable effects on the susceptibility of cancer, such as prostate cancer, lung cancer and gastric cancer. The E-cadherin, a calcium-dependent transmembrane glycoprotein encoded by CDH1 gene, is critical for epithelial construction, intercellular adhesion and cell migration. Some associations have been reported between single nucleotide polymorphisms and gastric cancer in the Chinese population.

objectiveTo investigate whether the single nucleotide polymorphism in CDH1 gene is associated with the susceptibility of gastric cancer in the Chinese population. MATERIAL AND

methodsThe genotypes of 5 known single nucleotide polymorphisms (rs33935154, rs121964871, rs121964874, rs121964875, rs121964876) were determined in 359 gastric cancer patients and 368 healthy controls. High resolution melting curve detection and sequencing analysis were used in the present study.

resultsThere is a statistical significance in the rs121964871 C>G polymorphism between gastric cancer patients and healthy controls (OR=1.769, 95%CI: 1.051-2.976). Elderly male individuals (>50 years of age) carrying this risk factor may be more susceptible to gastric cancer.

conclusionsThe results indicated that the rs121964871 C>G polymorphism is associated with the susceptibility of gastric cancer in the Chinese population, with some age and sex-dependent tendencies observed.

Indexed as

CDH1 geneGastric cancerSingle nucleotide polymorphism

Identifiers

PMID28352678
PMCPMC5152961
OpenAlexW2071384124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.