Evidence map›Paper›PMID 28352668›Full record

ArticleJCI insight2017

Genomic profiling reveals mutational landscape in parathyroid carcinomas.

Chetanya Pandya, Andrew V Uzilov, Justin Bellizzi, Chun Yee Lau, Aye S Moe, Maya Strahl, Wissam Hamou, Leah C Newman, Marc Y Fink, Yevgeniy Antipin and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Mutational patterns in a large cohort of parathyroid carcinomas.Journal of endocrinological investigation · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Parathyroid carcinoma: epidemiology and genetics.Endocrine oncology (Bristol, England) · 2026
    Review
  9. Article
  10. Avoiding overdiagnosis of parathyroid carcinoma.Virchows Archiv : an international journal of pathology · 2026
    Review
  11. Diagnosing the silent: the molecular landscape of non-functional parathyroid carcinoma.Virchows Archiv : an international journal of pathology · 2025
    Review
  12. Review
  13. Article
  14. Genotype-Phenotype Correlations in the Hyperparathyroidism-Jaw Tumor Syndrome.The Journal of clinical endocrinology and metabolism · 2025
    Review
  15. Review
  16. Article
  17. Journal of the Endocrine Society · 2025
    Article
  18. JBMR plus · 2025
    Article
  19. Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 4 countries.

Chetanya PandyaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrew V UzilovDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Justin BellizziCenter for Molecular Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Chun Yee LauDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Aye S MoeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Maya StrahlDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Wissam HamouDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Leah C NewmanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Marc Y FinkDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yevgeniy AntipinDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Willie YuCenter for Computational Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Mark StevensonAcademic Endocrine Unit, Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom.
Branca M CavacoMolecular Endocrinology Group, Molecular Pathobiology Research Centre Unit (UIPM) of the Portuguese Institute of Oncology from Lisbon Francisco Gentil (IPOLFG), Lisbon, Portugal.
Bin T TehLaboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore.
Rajesh V ThakkerAcademic Endocrine Unit, Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom.
Hans MorreauDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Eric E SchadtDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Robert SebraDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Shuyu D LiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrew ArnoldCenter for Molecular Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Rong ChenDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai · USUniversity of Connecticut · USLeiden University Medical Center · NLNational University of Singapore · SGOxford Centre for Diabetes, Endocrinology and Metabolism · GBUniversity of Oxford · GB

Funding

A New Disease Platform Leveraging Complex Drosophila and Mammalian ModelsU54OD020353 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAGAN, ROSS LEIGH · 2015 to 2019
$10.3M
Medical Research Council G1000467NIH HHS U54 OD020353Wellcome Trust
6 · The paper itself

Abstract

Parathyroid carcinoma (PC) is an extremely rare malignancy lacking effective therapeutic intervention. We generated and analyzed whole-exome sequencing data from 17 patients to identify somatic and germline genetic alterations. A panel of selected genes was sequenced in a 7-tumor expansion cohort. We show that 47% (8 of 17) of the tumors harbor somatic mutations in the

Indexed as

Gene Expression ProfilingMutationCohort StudiesCyclin D1HumansParathyroid NeoplasmsPhosphatidylinositol 3-KinasesProtein KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesTumor Suppressor ProteinsWnt Signaling PathwayADCK1 protein, humanCCND1 protein, humanCDC73 protein, humanCyclin D1MTOR protein, humanPhosphatidylinositol 3-KinasesProtein KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesTumor Suppressor Proteins

Identifiers

PMID28352668
PMCPMC5358487
OpenAlexW2603113849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.