ArticleJCI insight2017
Point mutations in murine
Open access · goldAbstract read
In one paragraph
Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Novel mutations of AXIN2 identified in a Chinese Congenital Heart Disease Cohort.Journal of human genetics · 2019Trial
- Streamlined identification of clinically and functionally relevant genetic regulators of lower-tract urogenital development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Modeling a variant of unknown significance in the Drosophila ortholog of the human cardiogenic gene NKX2.5.Disease models & mechanisms · 2023Article
- Application of 4-D ultrasound-derived regional strain and proteomics analysis inAmerican journal of physiology. Heart and circulatory physiology · 2023Article
- Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases.Frontiers in cardiovascular medicine · 2023Review
- Activation of Nkx2.5 transcriptional program is required for adult myocardial repair.Nature communications · 2022Article
- CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart.Genes & development · 2022Article
- Article
- Mending a broken heart:Disease models & mechanisms · 2021Review
- Atrial and Sinoatrial Node Development in the Zebrafish Heart.Journal of cardiovascular development and disease · 2021Review
- Machine Learning Driven Contouring of High-Frequency Four-Dimensional Cardiac Ultrasound Data.Applied sciences (Basel, Switzerland) · 2021Article
- Risk factors of postoperative acute kidney injury in patients with complex congenital heart disease and significance of early detection of serum transcription factor Nkx2.5.American journal of translational research · 2021Article
- Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility.Molecular metabolism · 2021Article
- The Mesenchymal Cap of the Atrial Septum and Atrial and Atrioventricular Septation.Journal of cardiovascular development and disease · 2020Review
- Experimental Rodent Models of Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2020Review
- Extracellular Matrix Disparities in anFrontiers in cardiovascular medicine · 2020Article
- Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease.Molecular metabolism · 2019Article
- Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors.Acta pharmacologica Sinica · 2019Review
- Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy.PLoS genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 6 countries.
Milena B FurtadoThe Jackson Laboratory, Bar Harbor, Maine, USA.
Julia C WilmannsAustralian Regenerative Medicine Institute, Monash University, Clayton, Australia.
Anjana ChandranAustralian Regenerative Medicine Institute, Monash University, Clayton, Australia.
Joelle PereraAustralian Regenerative Medicine Institute, Monash University, Clayton, Australia.
Olivia HonThe Jackson Laboratory, Bar Harbor, Maine, USA.
Christine BibenThe Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Taylor J WillowThe Jackson Laboratory, Bar Harbor, Maine, USA.
Hieu T NimAustralian Regenerative Medicine Institute, Monash University, Clayton, Australia.
Gurpreet KaurAustralian Regenerative Medicine Institute, Monash University, Clayton, Australia.
Stephanie SimondsDepartment of Physiology.
Qizhu WuMonash Biomedical Imaging, Monash University, Clayton, Australia.
David WilliansHeart Failure Research Group, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
Ekaterina SalimovaAustralian Regenerative Medicine Institute, Monash University, Clayton, Australia.
Nicolas PlachtaInstitute of Molecular and Cell Biology, A*STAR, Singapore.
James M DenegreThe Jackson Laboratory, Bar Harbor, Maine, USA.
Stephen A MurrayThe Jackson Laboratory, Bar Harbor, Maine, USA.
Diane FatkinMolecular Cardiology, Victor Chang Cardiac Research Institute, Darlinghurst, Australia.
Michael CowleyDepartment of Physiology.
James T PearsonDepartment of Physiology.
David KayeHeart Failure Research Group, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
Mirana RamialisonAustralian Regenerative Medicine Institute, Monash University, Clayton, Australia.
Richard P HarveyFaculty of Medicine and School of Biological and Biomolecular Sciences, University of New South Wales, Kensington, Australia.
Nadia A RosenthalThe Jackson Laboratory, Bar Harbor, Maine, USA.
Mauro W CostaThe Jackson Laboratory, Bar Harbor, Maine, USA.
Monash University · AUAustralian Regenerative Medicine Institute · AUJackson Laboratory · USBaker Heart and Diabetes Institute · AUCzech Academy of Sciences, Institute of Physiology · CZAgency for Science, Technology and Research · SGSt Vincent's Hospital Sydney · AUWalter and Eliza Hall Institute of Medical Research · AU
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9MNCI NIH HHS P30 CA034196
Abstract
Mutations in the
Indexed as
Disease Models, AnimalPoint MutationAnimalsGene Regulatory NetworksHeartHeart Defects, CongenitalHomeobox Protein Nkx-2.5HumansMiceMice, TransgenicPhenotypeWnt Signaling PathwayHomeobox Protein Nkx-2.5Nkx2-5 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.