ArticleFrontiers in nutrition2017
Neuroprotective Effects of Selected Microbial-Derived Phenolic Metabolites and Aroma Compounds from Wine in Human SH-SY5Y Neuroblastoma Cells and Their Putative Mechanisms of Action.
Article in Frontiers in nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Neuroprotective Effect of Physiological Circulating Phenolic Metabolites Against Oxidative Stress- and Neuroinflammation-Induced in Human Cellular Models.International journal of molecular sciences · 2026Article
- Nootropic foods in neurodegenerative diseases: mechanisms, challenges, and future.Translational neurodegeneration · 2025Review
- Effects of Phenolic Acids Produced from Food-Derived Flavonoids and Amino Acids by the Gut Microbiota on Health and Disease.Molecules (Basel, Switzerland) · 2024Review
- Interplay between Phytochemicals and the Colonic Microbiota.Nutrients · 2023Review
- Activity of Microbial-Derived Phenolic Acids and Their Conjugates against LPS-Induced Damage in Neuroblastoma Cells and Macrophages.Metabolites · 2023Article
- Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration.Nanomaterials (Basel, Switzerland) · 2022Review
- Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia.Molecular neurodegeneration · 2022Review
- Pomiferin Exerts Antineuroinflammatory Effects through Activating Akt/Nrf2 Pathway and Inhibiting NF-Mediators of inflammation · 2022Article
- Review
- Flavonoids as an Intervention for Alzheimer's Disease: Progress and Hurdles Towards Defining a Mechanism of Action.Brain plasticity (Amsterdam, Netherlands) · 2021Review
- Equol, a Blood-Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein, Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Article
- Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer's Disease.Nutrients · 2020Review
- Neuroprotective effects of urolithin A on HNutrition research and practice · 2020Article
- Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare.Frontiers in pharmacology · 2020Review
- Antioxidant Therapies for Neuroprotection-A Review.Journal of clinical medicine · 2019Review
- Review
- Chemical Characterization of an Encapsulated Red Wine Powder and Its Effects on Neuronal Cells.Molecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moderate wine consumption has shown the potential to delay the onset of neurodegenerative diseases. This study investigates the molecular mechanisms underlying the protective effects of wine-derived phenolic and aroma compounds in a neuroinflammation model based on SIN-1 stress-induced injury in SH-SY5Y neuroblastoma cells. Cell pretreatment with microbial metabolites found in blood after wine consumption, 3,4-dihydroxyphenylacetic (3,4-DHPA), 3-hydroxyphenylacetic acids and salicylic β-d-O-glucuronide, at physiologically concentrations (0.1-10 μM) resulted in increased cell viability versus SIN-1 control group (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.