ArticleBiotechnology reports (Amsterdam, Netherlands)2016
Evaluation of methods for pore generation and their influence on physio-chemical properties of a protein based hydrogel.
Article in Biotechnology reports (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Evaluation of the Biological Response to Coating 3D-Printed PLA Scaffolds with Coaxial Gelatin-Based Electrospun Fibers.Biomimetics (Basel, Switzerland) · 2026Article
- Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long-Gap Peripheral Nerve Injury.Advanced healthcare materials · 2025Article
- Hydrogel Design to Understand and Guide 3D Cell Migration.Regenerative engineering and translational medicine · 2025Review
- Tailoring of Physical Properties in Macroporous Poly(isocyanopeptide) Cryogels.Biomacromolecules · 2024Article
- The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives.Biomimetics (Basel, Switzerland) · 2024Review
- Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management.Drug delivery · 2022Article
- Alginate-Lysozyme Nanofibers Hydrogels with Improved Rheological Behavior, Printability and Biological Properties for 3D Bioprinting Applications.Nanomaterials (Basel, Switzerland) · 2022Article
- Functionalized Hydrogels for Cartilage Repair: The Value of Secretome-Instructive Signaling.International journal of molecular sciences · 2022Review
- Albumin Microspheres as "Trans-Ferry-Beads" for Easy Cell Passaging in Cell Culture Technology.Gels (Basel, Switzerland) · 2021Article
- BSA Hydrogel Beads Functionalized with a Specific Aptamer Library for CapturingInternational journal of molecular sciences · 2021Article
- Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration.Molecules (Basel, Switzerland) · 2021Review
- Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine.Gels (Basel, Switzerland) · 2021Article
- Image analysis method for heterogeneity and porosity characterization of biomimetic hydrogels.F1000Research · 2020Article
- Gelatin-polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics.Bioengineering & translational medicine · 2019Review
- Numerical Investigations of Hepatic Spheroids Metabolic Reactions in a Perfusion Bioreactor.Frontiers in bioengineering and biotechnology · 2019Article
- Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications.Journal of visualized experiments : JoVE · 2017Article
- Lectin-mediated reversible immobilization of human cells into a glycosylated macroporous protein hydrogel as a cell culture matrix.Scientific reports · 2017Article
- The Effect of Rosmarinic Acid on Neural Differentiation of Wartons Jelly-derived Mesenchymal Stem Cells in Two-dimensional and Three-dimensional Cultures using Chitosan-based Hydrogel.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different methods to create and manipulate pore sizes in hydrogel fabrication are available, but systematic studies are normally conducted with hydrogels made of synthetic chemical compounds as backbones. In this study, a hydrogel made of natural and abundant protein in combination with different, well-available techniques was used to produce different architectures within the hydrogel matrix. Pore sizes and distribution are compared and resulting hydrogel properties like swelling ratio, resistance towards external stimuli and enzymatic degradation were investigated. Porous hydrogels were functionalized and two cancer cell lines were successfully adhered onto the material. With simple methods, pores with a radius between 10 and 80 μm and channels of 25 μm radius with a length of several hundreds of μm could be created and analyzed with laser scanning confocal microscopy and electron microscopy respectively. Furthermore, the influence of different methods on swelling ratio, enzymatic degradation and pH and temperature resistance was observed.
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Registered trials
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