Evidence map›Paper›PMID 28352429›Full record

ArticleCardiology research2013

ACP1 Genetic Polymorphism and Coronary Artery Disease: Evidence of Effects on Clinical Parameters of Cardiac Function.

Fulvia Gloria-Bottini, Maria Banci, Patrizia Saccucci, Paolo Nardi, Mattia Scognamiglio, Federica Papetti, Sara Adanti, Andrea Magrini, Antonio Pellegrino, Egidio Bottini and 1 more

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Article in Cardiology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Fulvia Gloria-BottiniDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Maria BanciDepartment of Cardiology, Valmontone Hospital, Rome, Italy.
Patrizia SaccucciDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Paolo NardiDepartment of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Mattia ScognamiglioDepartment of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Federica PapettiDepartment of Cardiology, Valmontone Hospital, Rome, Italy.
Sara AdantiDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Andrea MagriniDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Antonio PellegrinoDepartment of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Egidio BottiniDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Luigi ChiarielloDepartment of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKinases and phosphatases have an important role in the susceptibility and clinical variability of cardiac diseases. We have recently reported an association between a phosphoprotein phosphatase controlled by Acid Phosphatase locus 1 (ACP1), and Coronary artery disease (CAD) suggesting an effect on the susceptibility to this disease. In the present note we have investigated a possible role of ACP1 in the variability of clinical parameters of cardiac function.

methodsWe have studied 345 subjects admitted to Valmontone Hospital for cardiovascular diseases: 202 subjects with CAD and 143 without CAD, 53 subjects admitted to Cardiac Surgery Division of Tor Vergata University were also considered.

resultsIn diabetic patients with CAD there is a significant negative association between Left ventricular ejection fraction (LVEF) and ACP1 S isoform concentration. Genotypes with high S isoform concentration show a lower value of LVEF as compared to genotypes with low S isoform concentration. We have also found a significant positive association between cNYHA class and ACP1 S isoform. After surgical intervention, in subjects with high S isoform concentration the decrease of LVEF is more marked as compared to subjects with low S isoform concentration. Overall these observations indicate that high S isoform activity has negative effects on cardiac function. The observation in patients undergoing cardiac surgery confirms the negative association between high S isoform activity and LVEF.

conclusionsThe present study suggests that ACP1 influences both susceptibility to CAD and clinical manifestations of the disease.

Indexed as

ACP1CADCardiovascular diseasesGenetic polymorphismsLVEFPhosphatases

Identifiers

PMID28352429
PMCPMC5358247
OpenAlexW2132045812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.