ArticleFrontiers in endocrinology2017
High-Fat Feeding Does Not Disrupt Daily Rhythms in Female Mice because of Protection by Ovarian Hormones.
Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Exogenous estradiol does not regulate daily metabolic rhythms underlying diet-induced obesity in male mice.PloS one · 2026Article
- Time-restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex-dependent study.The Journal of physiology · 2025Article
- The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research.Nature metabolism · 2025Review
- Circadian patterns of behaviour change during pregnancy in mice.The Journal of physiology · 2024Article
- The Estrous Cycle Coordinates the Circadian Rhythm of Eating Behavior in Mice.Journal of biological rhythms · 2024Article
- Article
- Eating Around the Clock: Circadian Rhythms of Eating and Metabolism.Annual review of nutrition · 2024Review
- Article
- Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior.Science advances · 2023Article
- Chronic environmental circadian disruption increases atherosclerosis and dyslipidemia in female, but not male,Frontiers in physiology · 2023Article
- Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice.Science (New York, N.Y.) · 2022Article
- Estrogens and the circadian system.Seminars in cell & developmental biology · 2022Review
- Article
- Optimization of Analysis of Circadian Rest-Activity Rhythm Using Cosinor Analysis in Mice.Psychiatry investigation · 2022Article
- Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons.International journal of molecular sciences · 2022Article
- Prolonged saturated, but not monounsaturated, high-fat feeding provokes anxiodepressive-like behaviors in female mice despite similar metabolic consequences.Brain, behavior, & immunity - health · 2021Article
- Creld2 function during unfolded protein response is essential for liver metabolism homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- A Guide to the Generation of a 6-Hydroxydopamine Mouse Model of Parkinson's Disease for the Study of Non-Motor Symptoms.Biomedicines · 2021Article
- High-fat feeding disrupts daily eating behavior rhythms in obesity-prone but not in obesity-resistant male inbred mouse strains.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Homeostatic Regulation of Estrus Cycle of Young Female Mice on Western Diet.Journal of the Endocrine Society · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Obesity in women is increased by the loss of circulating estrogen after menopause. Shift work, which disrupts circadian rhythms, also increases the risk for obesity. It is not known whether ovarian hormones interact with the circadian system to protect females from obesity. During high-fat feeding, male C57BL/6J mice develop profound obesity and disruption of daily rhythms. Since C57BL/6J female mice did not develop diet-induced obesity (during 8 weeks of high-fat feeding), we first determined if daily rhythms in female mice were resistant to disruption from high-fat diet. We fed female PERIOD2:LUCIFERASE mice 45% high-fat diet for 1 week and measured daily rhythms. Female mice retained robust rhythms of eating behavior and locomotor activity during high-fat feeding that were similar to chow-fed females. In addition, the phase of the liver molecular timekeeping (PER2:LUC) rhythm was not altered by high-fat feeding in females. To determine if ovarian hormones protected daily rhythms in female mice from high-fat feeding, we analyzed rhythms in ovariectomized mice. During high-fat feeding, the amplitudes of the eating behavior and locomotor activity rhythms were reduced in ovariectomized females. Liver PER2:LUC rhythms were also advanced by ~4 h by high-fat feeding, but not chow, in ovariectomized females. Together these data show circulating ovarian hormones protect the integrity of daily rhythms in female mice during high-fat feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.