Evidence map›Paper›PMID 28352102›Full record

ArticleScientific reports2017

PKCα diffusion and translocation are independent of an intact cytoskeleton.

Xin Hui, Benjamin Sauer, Lars Kaestner, Karsten Kruse, Peter Lipp

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xin HuiInstitute for Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Center for Molecular Signaling (PZMS), Medical Faculty, Saarland University, Homburg/Saar, Germany.
Benjamin SauerInstitute for Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Center for Molecular Signaling (PZMS), Medical Faculty, Saarland University, Homburg/Saar, Germany.
Lars KaestnerInstitute for Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Center for Molecular Signaling (PZMS), Medical Faculty, Saarland University, Homburg/Saar, Germany.
Karsten KruseNCCR Chemical Biology, Departments of Biochemistry and Theoretical Physics, University of Geneva, 30 quai Ernest-Ansermet, 1211, Geneva, Switzerland.
Peter LippInstitute for Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Center for Molecular Signaling (PZMS), Medical Faculty, Saarland University, Homburg/Saar, Germany. peter.lipp@uks.eu.ORCID 0000-0003-4728-9174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Translocation of cytosolic cPKC to the plasma membrane is a key event in their activation process but its exact nature is still unclear with particular dispute whether sole diffusion or additional active transport along the cell's cytoskeleton contributes to cPKC's dynamics. This was addressed by analyzing the recruitment behavior of PKCα while manipulating the cytoskeleton. Photolytic Ca

Indexed as

ActinsCalciumCytoskeletonFluorescent Antibody TechniqueHEK293 CellsHumansMicroscopy, FluorescenceMicrotubulesProtein BindingProtein Kinase C-alphaProtein MultimerizationProtein TransportActinsCalciumPRKCA protein, humanProtein Kinase C-alpha

Identifiers

PMID28352102
PMCPMC5428563

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.