ArticleScientific reports2017
Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Targeting the aldosterone-mineralocorticoid receptor pathway in cardiovascular-kidney-metabolic syndrome.Nature reviews. Nephrology · 2026Review
- Salt and chronic kidney disease.Nature reviews. Nephrology · 2026Review
- Early reduction of skin potassium without sodium accumulation in the pathogenesis of salt sensitivity in primary aldosteronism.Frontiers in pharmacology · 2025Article
- The Effects of Aldosterone on Hypertension-Associated Kidney Injury in a Tg-hAS Mouse Model.Biology · 2024Article
- Aldosterone-producing Multiple Micronodules With Several DifferentJCEM case reports · 2024Article
- Genetics of Primary Aldosteronism.Hypertension (Dallas, Tex. : 1979) · 2022Review
- DNA Methylation of the Angiotensinogen Gene,International journal of molecular sciences · 2021Review
- Effects of intron conversion in the humanThe Journal of biological chemistry · 2020Article
- Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.Scientific reports · 2020Article
- Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation.The Journal of clinical investigation · 2020Article
- Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.Nature communications · 2019Article
- Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.Experimental eye research · 2019Review
- Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice.Scientific reports · 2019Article
- Animal Models of Hypertension: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Determination of the psychometric properties of the Patients' Self-Efficacy Scale in blood pressure patients.Interventional medicine & applied science · 2018Article
- Mouse Models of Primary Aldosteronism: From Physiology to Pathophysiology.Endocrinology · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is one of the most important, preventable causes of premature morbidity and mortality in the developed world. Aldosterone is a major mineralocorticoid hormone that plays a key role in the regulation of blood pressure and is implicated in the pathogenesis of hypertension and heart failure. Aldosterone synthase (AS, cytochrome P450 11B2, cyp11B2) is the sole enzyme responsible for the production of aldosterone in humans. To determine the effects of increased expression of human aldosterone synthase (hAS) on blood pressure (BP), we established transgenic mice carrying the hAS gene (cyp11B2). We showed that hAS overexpression increased levels of aldosterone in hAS
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.