ArticleScientific reports2017
Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Effect of Acupuncture on Neuroplasticity of Stroke Patients with Motor Dysfunction: A Meta-Analysis of fMRI Studies.Neural plasticity · 2021Pooled it
- Association of sexual dysfunctions according to DSM-5 criteria with structural brain differences in women and men from the Hamburg City Health Study.Dialogues in clinical neuroscience · 2026Article
- Genital-prioritized attentional bias in lifelong premature ejaculation: behavioral evidence from eye-tracking and machine learning.International journal of impotence research · 2026Article
- Article
- Assessing neurobiology of lifelong premature ejaculation through brain MRI structural similarity gradient.European radiology experimental · 2025Article
- Abnormal grey matter in identifying primary intravaginal anejaculation patients from healthy controls: a voxel-based morphometry analysis.Sexual medicine · 2025Article
- Glans penis electric stimulation modulates cerebral activity and functional connectivity in lifelong premature ejaculation revealed by functional MRI.Scientific reports · 2025Article
- Task Modulation of Resting-State Functional Gradient Stability in Lifelong Premature Ejaculation: An FMRI Study.eNeuro · 2025Article
- The role of acupuncture in treating premature ejaculation and its probable neurobiological mechanism.Basic and clinical andrology · 2024Review
- Altered regional brain activity and functional connectivity in primary intravaginal anejaculation patients revealed by resting-state fMRI.Asian journal of andrology · 2024Article
- Altered brain activity associated with premature ejaculation improved by electroacupuncture in rats.Sexual medicine · 2024Article
- Abnormal cortical surface-based spontaneous and functional connectivity in the whole brain in lifelong premature ejaculation patients.Asian journal of andrology · 2023Article
- Multivariate Pattern Analysis of Lifelong Premature Ejaculation Based on Multiple Kernel Support Vector Machine.Frontiers in psychiatry · 2022Article
- Convergent and Divergent Structural Connectivity of Brain White Matter Network Between Patients With Erectile Dysfunction and Premature Ejaculation: A Graph Theory Analysis Study.Frontiers in neurology · 2022Article
- Potential biomarkers for distinguishing primary from acquired premature ejaculation: A diffusion tensor imaging based network study.Frontiers in neuroscience · 2022Article
- Smaller volume and altered functional connectivity of the amygdala in patients with lifelong premature ejaculation.European radiology · 2021Article
- Higher inter-hemispheric homotopic connectivity in lifelong premature ejaculation patients: a pilot resting-state fMRI study.Quantitative imaging in medicine and surgery · 2021Article
- Abnormal degree centrality in lifelong premature ejaculation patients: an fMRI study.Brain imaging and behavior · 2021Article
- Changes in the Amplitude of Low-Frequency Fluctuation in Patients With Lifelong Premature Ejaculation by Resting-State Functional MRI.Sexual medicine · 2021Article
- Reconfiguration of Dynamic Functional Connectivity States in Patients With Lifelong Premature Ejaculation.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though lifelong premature ejaculation (PE) is highly prevalent, few studies have investigated the neural mechanisms underlying PE. The extent and pattern of brain activation can be determined through a version of functional magnetic resonance imaging (fMRI) with erotic picture stimuli (task fMRI) and a resting-state fMRI (rs fMRI). We showed that the brain activity in the left inferior frontal gyrus and left insula was decreased both during the task and in the resting state, while there was higher activation in the right middle temporal gyrus during the task. Higher functional connectivity was found in PE between those three brain areas and the bilateral middle cingulate cortex, right middle frontal gyrus and supplementary motor area. Moreover, the brain activity had positive correlation with clinical rating scales, such as intravaginal ejaculatory latency time (IELT) and the Chinese Index of Premature Ejaculation (CIPE). These findings revealed that brain responses and functional integration in certain brain areas are impaired in cases of PE, which was consistently supported by multiple measurements obtained using a task and rs fMRI approach.
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