ArticleThe Journal of experimental medicine2017
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Human inborn errors of the phagocyte respiratory burst: Chronic granulomatous disease and beyond.Journal of human immunity · 2026Article
- Chronic granulomatous disease: Clinical, microbial, and genetic findings in 39 Colombian patients.Journal of human immunity · 2026Article
- Molecular Views into the Synthesis and Activation of FlavocytochromeAntioxidants (Basel, Switzerland) · 2026Review
- CYBC1 Drives Glioblastoma Progression via Reactive Oxygen Species and NF-κB Pathways.Cancer research and treatment · 2025Article
- Cancer Cell-Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Chronic granulomatous disease: lessons in cell biology from monogenic immunodeficiency.Clinical and experimental immunology · 2025Review
- Diagnosis of Chronic Granulomatous Disease: Strengths and Challenges in the Genomic Era.Journal of clinical medicine · 2024Review
- A nox2/cybb zebrafish mutant with defective myeloid cell reactive oxygen species production displays normal initial neutrophil recruitment to sterile tail injuries.G3 (Bethesda, Md.) · 2024Article
- Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multidimensional Response Surface Methodology for the Development of a Gene Editing Protocol for p67Human gene therapy · 2024Article
- Inflammatory Complications in Chronic Granulomatous Disease.Journal of clinical medicine · 2024Review
- Clinical presentation, diagnosis, and treatment of chronic granulomatous disease.Frontiers in pediatrics · 2024Review
- Structure, Activation, and Regulation of NOX2: At the Crossroad between the Innate Immunity and Oxidative Stress-Mediated Pathologies.Antioxidants (Basel, Switzerland) · 2023Review
- ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Identification of novel proteins involved in P2X7-mediated signaling cascades.Purinergic signalling · 2022Article
- EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling.eLife · 2022Article
- Review
- Chronic Granulomatous Disease: a Comprehensive Review.Clinical reviews in allergy & immunology · 2021Review
- Clinical and Immunological Characteristics of 63 Patients with Chronic Granulomatous Disease: Hacettepe Experience.Journal of clinical immunology · 2021Article
- Beyond the Extra Respiration of Phagocytosis: NADPH Oxidase 2 in Adaptive Immunity and Inflammation.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
27 authors at 3 institutions in 1 country.
David C ThomasDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.
Simon ClareWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.
John M SowerbyDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.
Mercedes PardoWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.ORCID 0000-0002-3477-9695
Jatinder K JussDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.
David A GouldingWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.
Louise van der WeydenWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.
Daniel StoristeanuDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.ORCID 0000-0003-2681-518X
Ananth PrakashEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, England, UK.
Marion EspéliDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.ORCID 0000-0001-5005-1664
Shaun FlintDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.ORCID 0000-0002-5282-9334
James C LeeDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.ORCID 0000-0001-5711-9385
Kim HoenderdosCambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, England, UK.ORCID 0000-0001-8499-9832
Leanne KaneWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.ORCID 0000-0002-2241-8120
Katherine HarcourtWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.
Subhankar MukhopadhyayWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.
Yagnesh UmraniaCambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, England, UK.ORCID 0000-0003-0366-901X
Robin AntrobusCambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, England, UK.
James A NathanCambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, England, UK.ORCID 0000-0002-0248-1632
David J AdamsWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.ORCID 0000-0001-9490-0306
Alex BatemanEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, England, UK.
Jyoti S ChoudharyWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England, UK.ORCID 0000-0003-0881-5477
Paul A LyonsDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.ORCID 0000-0001-7035-8997
Alison M CondliffeDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.ORCID 0000-0002-6697-8648
Edwin R ChilversDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.ORCID 0000-0002-4230-9677
Gordon DouganDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK kgcs2@cam.ac.uk gd1@sanger.ac.uk.ORCID 0000-0003-0022-965X
Kenneth G C SmithDepartment of Medicine, University of Cambridge, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, England, UK.ORCID 0000-0003-3829-4326
University of Cambridge · GBWellcome Sanger Institute · GBEuropean Bioinformatics Institute · GB
Funding
Medical Research Council MR/L019027/1Wellcome Trust 079895Wellcome Trust 098051Wellcome Trust 102770/Z/13/ZWellcome Trust 105920/2/14/2
Abstract
The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91
Indexed as
AnimalsCytochrome b GroupEndoplasmic ReticulumHEK293 CellsHumansImmunity, InnateMacrophagesMembrane GlycoproteinsMembrane ProteinsMiceMice, Inbred C57BLNADPH Oxidase 2NADPH OxidasesNeutrophilsPhagocytesPhagocytosisCyba protein, mouseCybb protein, mouseCytochrome b GroupEros protein, mouseMembrane GlycoproteinsMembrane ProteinsNADPH Oxidase 2NADPH OxidasesReactive Oxygen Species
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.