Evidence map›Paper›PMID 28351936›Full record

ArticleBlood2017

Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models.

Keina M C Dourado, June Baik, Vanessa K P Oliveira, Miriam Beltrame, Ami Yamamoto, Charles P Theuer, Camila A V Figueiredo, Michael R Verneris, Rita C R Perlingeiro

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. TGF-β superfamily co-receptors in cancer.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Endoglin Targeting: Lessons Learned and Questions That Remain.International journal of molecular sciences · 2020
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Keina M C DouradoLillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN.
June BaikLillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN.
Vanessa K P OliveiraLillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN.
Miriam BeltrameLaboratory for the Diagnosis of Onco-Hematological Disorders, Curitiba, Brazil.
Ami YamamotoLillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN.
Charles P TheuerTRACON Pharmaceuticals, Inc, San Diego, CA; and.
Camila A V FigueiredoInstituto de Ciencias da Saude, Federal University of Bahia, Salvador, Brazil.
Michael R VernerisDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Rita C R PerlingeiroLillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN.ORCID 0000-0001-9412-1118
University of Minnesota · USUniversidade Federal da Bahia · BRInstituto de Neurologia de Curitiba · BRTracon Pharmaceuticals (United States) · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
TRAINING IN HEMOGLOBIN &CELL MEMBRANE RESEARCHT32HL007062 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller, Gregory M Vercellotti · 1985 to 2026
$10.3M
NCI NIH HHS P30 CA077598NHLBI NIH HHS T32 HL007062
6 · The paper itself

Abstract

Endoglin (CD105), a receptor of the transforming growth factor-β superfamily, has been reported to identify functional long-term repopulating hematopoietic stem cells, and has been detected in certain subtypes of acute leukemias. Whether this receptor plays a functional role in leukemogenesis remains unknown. We identified endoglin expression on the majority of blasts from patients with acute myeloid leukemia (AML) and acute B-lymphoblastic leukemia (B-ALL). Using a xenograft model, we find that CD105

Indexed as

AdolescentAgedAged, 80 and overAnimalsAntibodies, MonoclonalAntibodies, NeoplasmBlast CrisisChildChild, PreschoolEndoglinFemaleHumansInfantJurkat CellsLeukemia, Myeloid, AcuteMaleAntibodies, MonoclonalAntibodies, NeoplasmcarotuximabEndoglinENG protein, humanNeoplasm Proteins

Identifiers

PMID28351936
PMCPMC5418640
OpenAlexW2600765765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.