Evidence map›Paper›PMID 28351935›Full record

ArticleBlood2017

Bidirectional immune tolerance in nonmyeloablative MHC-mismatched BMT for murine β-thalassemia.

Shuyu E, Aman Seth, Peter Vogel, Matt Sommers, Taren Ong, Asha B Pillai

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shuyu EDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.
Aman SethDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.
Peter VogelDivision of Veterinary Pathology, Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.
Matt SommersDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.
Taren OngDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.
Asha B PillaiDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-0488-3790
St. Jude Children's Research Hospital · US

Funding

NOVEL INNATE MECHANISMS OF IMMUNE TOLERANCE INDUCTION IN ALLOGENEIC HCT FOR HEMOGLOBINOPATHIESR01HL133462 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PILLAI, ASHA BHASKARAN · 2018 to 2021
$1.7M
REGULATORY T CELLS, MIXED CHIMERISM: A NOVEL TRANSPLANT STRATEGY FOR THALASSEMIASK08HL088260 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PILLAI, ASHA BHASKARAN · 2008 to 2012
$653k
NOVEL INNATE MECHANISMS OF IMMUNE TOLERANCE INDUCTION IN ALLOGENEIC HCT FOR HEMOGLOBINOPATHIESR56HL125449 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PILLAI, ASHA BHASKARAN · 2015 to 2015
$446k
NHLBI NIH HHS K08 HL088260NHLBI NIH HHS R01 HL133462NHLBI NIH HHS R56 HL125449
6 · The paper itself

Abstract

Nonmyeloablative conditioning using total lymphoid irradiation (TLI) and rabbit antithymocyte serum (ATS) (the murine preclinical equivalent of antithymocyte globulin [ATG]) facilitates immune tolerance after bone marrow transplantation (BMT) across major histocompatibility complex (MHC) disparities and may be a useful strategy for nonmalignant disorders. We previously reported that donor effector T-cell function and graft-versus-host disease (GVHD) are regulated via recipient invariant natural killer T-cell (iNKT) interleukin-4-driven expansion of donor Foxp3

Indexed as

Immune ToleranceAdoptive TransferAnimalsAntilymphocyte Serumbeta-ThalassemiaBone Marrow TransplantationCyclophosphamideDisease Models, AnimalGraft SurvivalGraft vs Host DiseaseLymphatic IrradiationMajor Histocompatibility ComplexMiceMice, Inbred BALB CMice, Mutant StrainsModels, ImmunologicalAntilymphocyte SerumCyclophosphamide

Identifiers

PMID28351935
PMCPMC5454334
OpenAlexW2602389571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.