ArticleClinical allergy1988
Influence of atopy on the clinical manifestations of coronavirus infection in adult volunteers.
Article in Clinical allergy, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- The effect of inhaled and intranasal sodium cromoglycate on symptoms of upper respiratory tract infections.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1996Trial
- A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers.Antiviral research · 1990Trial
- The effect of intranasal nedocromil sodium on viral upper respiratory tract infections in human volunteers.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1990Trial
- Article
- The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.Journal of virology · 2008Article
- An adult model of exclusive viral wheeze: inflammation in the upper and lower respiratory tracts.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2003Article
- The common cold.Primary care · 1996Review
- The Use of Antiallergic and Antiasthmatic Drugs in Viral Infections of the Upper Respiratory Tract.Clinical immunotherapeutics · 1996Article
- Effect of experimental influenza A virus infection on isolation of Streptococcus pneumoniae and other aerobic bacteria from the oropharynges of allergic and nonallergic adult subjects.Infection and immunity · 1995Article
- Amplified rhinovirus colds in atopic subjects.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1994Article
- Signs and symptoms in common colds.Epidemiology and infection · 1993Article
- A view from the Common Cold Unit.Antiviral research · 1992Review
- Rhinovirus 39 infection in allergic and nonallergic subjects.The Journal of allergy and clinical immunology · 1992Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an attempt to understand the relationship between viral upper respiratory tract infection and the underlying virological and immunological mechanisms, thirty-four volunteers were inoculated intranasally with coronavirus 229E; subsequent virus shedding and/or antibody rises, indicating active infection, were observed in twenty-nine. There was a greater increase in independently measured scores of clinical severity, e.g. cold symptoms, in those with detectable IgE in nasal secretions (P less than 0.01). A similar association was found between clinical scores and serum IgE concentrations greater than or equal to 150 IU/ml, but the relationship with systemic atopy, as assessed by skin-prick tests to common allergens, was less marked. A more detailed study of twelve of the infected volunteers failed to explain these findings on the basis of mast cell mediator release, as concentrations of leukotriene B4, the sulphidopeptide leukotriene C4, and histamine, were not appreciably elevated in the nasal secretions following virus inoculation. Similarly, there was no evidence that circulating coronavirus specific IgE was produced. Thus, this study suggest that atopy may be related to the severity of cold symptoms produced by coronavirus 229E, although the exact connection has yet to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.