Evidence map›Paper›PMID 28351423›Full record

ArticleGenome biology2017

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment.

Tina Wang, Brian Tsui, Jason F Kreisberg, Neil A Robertson, Andrew M Gross, Michael Ku Yu, Hannah Carter, Holly M Brown-Borg, Peter D Adams, Trey Ideker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 2 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 2 syntheses or guidelines pooled it, 325 citations in OpenAlex.

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128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tina WangDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Brian TsuiDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Jason F KreisbergDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Neil A RobertsonBeatson Institute for Cancer Research and University of Glasgow, Glasgow, UK.
Andrew M GrossDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Michael Ku YuDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Hannah CarterDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Holly M Brown-BorgDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58202, USA.
Peter D AdamsBeatson Institute for Cancer Research and University of Glasgow, Glasgow, UK.
Trey IdekerDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA. tideker@ucsd.edu.
University of California, San Diego · USCancer Research UK Scotland Institute · GBSanford Burnham Prebys Medical Discovery Institute · USUniversity of North Dakota · US

Funding

STRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI GARCIA, BENJAMIN A · 2008 to 2022
$28.3M
SYNTHETIC SYSTEMSP50GM085764 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HASTY, JEFF M, IDEKER, TREY · 2010 to 2018
$23.3M
TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Network approaches to identify cancer drivers from high-dimensional tumor dataDP5OD017937 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARTER, HANNAH KATHRYN · 2013 to 2017
$1.9M
Role of growth hormone in thiol metabolism, stress resistance and agingR01AG034206 · NIA · UNIVERSITY OF NORTH DAKOTA · PI BROWN-BORG, HOLLY M. · 2009 to 2013
$1.4M
Role of GH on thiol metabolism, stress resistance and agingK02AG038509 · NIA · UNIVERSITY OF NORTH DAKOTA · PI BROWN-BORG, HOLLY M. · 2010 to 2014
$575k
NIA NIH HHS K02 AG038509NIA NIH HHS P01 AG031862NIA NIH HHS R01 AG034206NIGMS NIH HHS P41 GM103504NIGMS NIH HHS P50 GM085764NIGMS NIH HHS T32 GM008666NIH HHS DP5 OD017937
6 · The paper itself

Abstract

backgroundGlobal but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by conditions that increase lifespan. Mice are particularly appealing organisms for studies of mammalian aging; however, epigenetic clocks have thus far been formulated only in humans.

resultsWe first examined whether mice and humans experience similar patterns of change in the methylome with age. We found moderate conservation of CpG sites for which methylation is altered with age, with both species showing an increase in methylome disorder during aging. Based on this analysis, we formulated an epigenetic-aging model in mice using the liver methylomes of 107 mice from 0.2 to 26.0 months old. To examine whether epigenetic aging signatures are slowed by longevity-promoting interventions, we analyzed 28 additional methylomes from mice subjected to lifespan-extending conditions, including Prop1

conclusionsThis study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers.

Indexed as

Caloric RestrictionEpigenomicsAgingAnimalsCluster AnalysisCpG IslandsDNA MethylationDwarfismEpigenesis, GeneticFemaleGene Expression ProfilingHumansLiverLongevityMaleMiceSirolimusAgingDNA methylationEpigenetic agingEpigenomics

Identifiers

PMID28351423
PMCPMC5371228
OpenAlexW2599102161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.