ArticleFluids and barriers of the CNS2017
Cerebrospinal fluid abnormalities in meningeosis neoplastica: a retrospective 12-year analysis.
Article in Fluids and barriers of the CNS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- "Proteinjury": a universal pathological mechanism mediated by cerebrospinal fluid in neurodegeneration and trauma.Frontiers in cell and developmental biology · 2025Review
- Clinical characteristics and analysis of cerebrospinal fluid biochemical, tumor markers and cytologic indices in 209 patients with meningeal carcinomatosis: a cross-sectional study.Frontiers in oncology · 2025Article
- The landscape and clinical impact of tumor-associated macrophages and PD-L1 in primary breast cancers and their brain metastases.Frontiers in immunology · 2025Article
- Article
- Integrins and the Metastasis-like Dissemination of Acute Lymphoblastic Leukemia to the Central Nervous System.Cancers · 2023Review
- Cerebrospinal fluid protein levels are elevated 100 times in a Leptomeningeal metastasis patient: a case report and literature review.Frontiers in neuroscience · 2023Article
- Spontaneous Hind Limb Paralysis Due to Acute Precursor B Cell Leukemia in RAG1-deficient Mice.Journal of molecular neuroscience : MN · 2022Article
- Rapidly progressive dementias - aetiologies, diagnosis and management.Nature reviews. Neurology · 2022Review
- Cerebrospinal fluid findings in patients with hematologic neoplasms and meningeal infiltration.Acta neurologica Belgica · 2021Article
- [Diagnostic Value of Locally Produced Tumor Markers and Blood Brain Barrier Integrity in Lung Cancer Patients with Leptomeningeal Metastasis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021Article
- Point-of-care detection of lactate in cerebrospinal fluid.Intensive care medicine experimental · 2021Article
- Macrophages in Giemsa-stained cerebrospinal fluid specimens predict carcinomatous meningitis.Oncology letters · 2020Article
- A rare case of malignant meningitis from a likely bronchogenic melanoma primary cancer.Oxford medical case reports · 2019Article
- Leptomeningeal Metastasis: The Role of Cerebrospinal Fluid Diagnostics.Frontiers in neurology · 2019Article
- Response.Clinical medicine (London, England) · 2018Article
- Meningeal carcinomatosis: three case-reports.World journal of surgical oncology · 2018Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeningeosis neoplastica is a diffuse metastatic spread of tumor cells in the subarachnoid space. Although first recognized in 1870, systematic investigations regarding cerebrospinal fluid (CSF) constituents in this condition are scarce.
methodsRoutine CSF samples analyzed from 2001 to 2012 at the Laboratory of Clinical Neurochemistry, University of Göttingen, were re-evaluated. Patients, whose CSF contained malignant cells were included in this study.
resultsPatients (n = 132, age 59.1 ± 29.1, 58% women) were identified, whose CSF contained malignant cells. The most frequent primary tumor was breast cancer (32.6%), followed by lung cancer (25.0%) and hematologic malignancies (21.2%). The most frequent clinical symptoms were affections of cranial nerves (41.7%), psychiatric abmormalities (32.6%) and radicular lesions of the lower extremities (20.5%). CSF cell counts ranged from 0 to 4692 cells/μl (median 4 cells/μl) and were elevated in 50%. The CSF-to-serum albumin ratio was abnormal in 69.4%. It ranged from 1.8 to 330 x 10
conclusionIn approximately 50% of CSF samples with meningeosis neoplastica the CSF cell count is not elevated. Diagnosis may be missed when only CSF samples with elevated cell counts are subjected to cytological analysis. CSF lactate and protein and the CSF-to-serum albumin ratio are frequently increased in meningeosis neoplastica. The differential diagnosis between meningeosis neoplastica and central nervous infections, in particular tuberculous or fungal meningitis, can be difficult.
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