Evidence map›Paper›PMID 28351378›Full record

ArticleBMC pediatrics2017

Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins.

Li-Xiao Xu, Yuan Lv, Yan-Hong Li, Xin Ding, Ying Wang, Xing Han, Ming-Hua Liu, Bin Sun, Xing Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
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  7. Review
  8. Article
  9. Melatonin Is Neuroprotective inInternational journal of molecular sciences · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Melatonin for Neonatal Encephalopathy: From Bench to Bedside.International journal of molecular sciences · 2021
    Review
  14. Review
  15. Frontiers in cell and developmental biology · 2021
    Article
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Li-Xiao XuInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, 215006, China.
Yuan LvDepartment of Neonatology, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.
Yan-Hong LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, 215006, China.
Xin DingDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, 215006, China.
Ying WangDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, 215006, China.
Xing HanDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, 215006, China.
Ming-Hua LiuDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, 215006, China.
Bin SunDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, 215006, China. sunyu0628@126.com.
Xing FengDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, 215006, China. xing_feng66@suda.edu.cn.
Soochow University · CNNorthern Jiangsu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults. However, little is known regarding the mechanisms that involve the protective effects of melatonin in the brain and peripheral tissues after HIE. The present study aimed to examine the effects of melatonin on multiple organs, and the expression of edema related proteins in a neonatal rat model of hypoxic-ischemic brain damage (HIBD).

methodsOne hundred ninety-two neonatal rats were randomly divided into three subgroups that underwent a sham surgery or HIBD. After the HIBD or sham-injury, the rats received an intraperitoneal injection of melatonin or an equal volume vehicle, respectively. We investigated the effects of melatonin on brain, kidney, and colon edema via histological examination and the expression of edema related proteins, including AQP-4, ZO-1 and occludin, via qPCR and western blot.

resultsOur data indicated (1) Melatonin reduced the histological injury in the brain and peripheral organs induced by HIBD as assessed via H-E staining and transmission electron microscopy. (2) Melatonin alleviated the HIBD-induced cerebral edema characterized by increased brain water content. (3) HIBD induced significant changes of edema related proteins, such as AQP-4, ZO-1 and occludin, and these changes were partially reversed by melatonin treatment.

conclusionsThese findings provide substantial evidence that melatonin treatment has protective effects on the brain and peripheral organs after HIBD, and the edema related proteins, AQP4, ZO-1, and occludin, may indirectly contribute tothe mechanism of the edema protection by melatonin.

Indexed as

AnimalsAnimals, NewbornBiomarkersBlotting, WesternBrain EdemaColonic DiseasesEdemaHypoxia-Ischemia, BrainInjections, IntraperitonealKidney DiseasesMelatoninMicroscopy, Electron, TransmissionNeuroprotective AgentsRandom AllocationRatsRats, Sprague-DawleyBiomarkersMelatoninNeuroprotective AgentsAquaporin-4EdemaHypoxic-ischemic encephalopathyMelatoninOccludinZonula occludens-1

Identifiers

PMID28351378
PMCPMC5371222
OpenAlexW2603610617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.