ArticleBMC cancer2017
Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy.
Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Clinical Association of Negative Lymph Nodes With Adjuvant Chemotherapy in Patients With T3N0 Rectal Cancer.Gastroenterology research and practice · 2025Article
- Examined lymph node numbers influence prognosis in rectal cancer treated with neoadjuvant therapy.Cancer pathogenesis and therapy · 2023Article
- Risk factors for long-term survival in patients with ypN+ M0 rectal cancer after radical anterior resection.BMC gastroenterology · 2022Article
- Construction and evaluation of prognostic models for esophageal cancer patients with distant and non-distant metastases: providing a reference process for clinical diagnosis and treatment.Journal of gastrointestinal oncology · 2021Article
- The assessment of risk factors for long-term survival outcome in ypN0 patients with rectal cancer after neoadjuvant therapy and radical anterior resection.World journal of surgical oncology · 2021Article
- [Positive lymph node ratio ≥0.16 is an independent risk factor affecting the prognosis of patients with esophageal cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- The Number of Negative Lymph Nodes is Positively Associated with Survival in Esophageal Squamous Cell Carcinoma Patients in China.Open medicine (Warsaw, Poland) · 2020Article
- What Is the Minimum Number of Examined Lymph Nodes After Neoadjuvant Therapy in Rectal Cancer?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery.Oncotarget · 2018Article
- Positive relationship between number of negative lymph nodes and duration of gallbladder cancer cause-specific survival after surgery.Cancer management and research · 2018Article
- Correlation of Cancer Stem-Cell Markers OCT4, SOX2, and NANOG with Clinicopathological Features and Prognosis in Operative Patients with Rectal Cancer.Yonsei medical journal · 2018Article
- An increased number of negative lymph nodes is associated with a higher immune response and longer survival in colon cancer patients.Cancer management and research · 2018Article
- A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: neutrophil lymphocyte ratio/albumin ratio.Oncotarget · 2017Article
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6 authors.
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Abstract
backgroundNegative lymph node (NLN) count has been reported to provide more accurate prognostic information than the N stage alone in patients with rectal cancer (RC). Since preoperative radiotherapy (Pre-RT) can significantly affect the LN status, it is unclear whether NLN count still has prognostic value count on survival of patients with RC who received Pre-RT.
methodsIn this study, clinicopathological characteristics, number of positive LNs and survival time were collected from Surveillance, Epidemiology, and End Results Program (SEER)-registered RC patients. Univariate and multivariate Cox proportional hazards models were used to assess the risk factors for survival.
resultsX-tile plots identified 9 (P < 0.001) as the optimal cutoff NLN value to divide the patients into high and low risk subsets in terms of cause specific survival (CSS). NLN count was validated as independently prognostic factor in univariate and multivariate analysis (P < 0.001). Subgroup analysis showed that NLN count was an independently prognostic factor for patients with stage ypII (P = 0.002) and ypIII (P < 0.001).
conclusionsOur results firmly demonstrated that NLN count provides accurate prognostic information for RC patients with Pre-RT.
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