Evidence map›Paper›PMID 28350990›Full record

ArticleDevelopmental cell2017

The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species.

Evan A Bordt, Pascaline Clerc, Brian A Roelofs, Andrew J Saladino, László Tretter, Vera Adam-Vizi, Edward Cherok, Ahmed Khalil, Nagendra Yadava, Shealinna X Ge and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 357 papers.

0numbers the graph read from it
0cells of the map it votes in
357citing papers in PubMed
21.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

357 citing papers in PubMed, 572 citations in OpenAlex.

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297 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Evan A BordtDepartment of Anesthesiology, The Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Pascaline ClercDepartment of Anesthesiology, The Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Brian A RoelofsDepartment of Anesthesiology, The Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Andrew J SaladinoDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Baltimore, MD 21201, USA.
László TretterMTA-SE Laboratory for Neurobiochemistry, Department of Medical Biochemistry, Semmelweis University, Budapest 1094, Hungary.
Vera Adam-ViziMTA-SE Laboratory for Neurobiochemistry, Department of Medical Biochemistry, Semmelweis University, Budapest 1094, Hungary.
Edward CherokCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Ahmed KhalilPioneer Valley Life Sciences Institute, Springfield, MA 01109, USA; Baystate Medical Center, Springfield, MA 01109, USA.
Nagendra YadavaPioneer Valley Life Sciences Institute, Springfield, MA 01109, USA; Baystate Medical Center, Springfield, MA 01109, USA; Department of Biology, University of Massachusetts, Amherst, MA 01003, USA.
Shealinna X GeDepartment of Anesthesiology, The Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
T Chase FrancisDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Nolan W KennedyDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Lora K PictonDepartment of Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tanya KumarDepartment of Anesthesiology, The Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Sruti UppuluriDepartment of Anesthesiology, The Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Alexandrea M MillerDepartment of Anesthesiology, The Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kie ItohDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mariusz KarbowskiCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Hiromi SesakiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
R Blake HillDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Brian M PolsterDepartment of Anesthesiology, The Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: bpolster@anes.umm.edu.
University of Maryland, Baltimore · USJohns Hopkins University · USBaystate Medical Center · USMedical College of Wisconsin · USSemmelweis University · HU

Funding

SPECTRIN-DEPENDENT MEMBRANE DOMAINS IN THE DEVELOPING CNSP01HD016596 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI MCKENNA, MARY C · 1985 to 2013
$12.8M
Structural Biology of Mitochondrial FissionR01GM067180 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI HILL, R BLAKE · 2004 to 2022
$6.0M
Mitochondrial Fusion and DivisionR01GM089853 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2010 to 2014
$2.1M
Novel Mechanisms of Microglial Neurotoxicity at Physiological OxygenR01NS085165 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI POLSTER, BRIAN M · 2013 to 2017
$1.7M
Proteolytic Fragments and Mitochondrial Dysfunction in TBIR01NS064978 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI POLSTER, BRIAN M · 2009 to 2012
$1.0M
Mitochondrial Structural and Functional Remodeling in Microglial ActivationR21NS096538 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI POLSTER, BRIAN M · 2016 to 2017
$424k
NICHD NIH HHS P01 HD016596NIGMS NIH HHS R01 GM067180NIGMS NIH HHS R01 GM089853NINDS NIH HHS R01 NS064978NINDS NIH HHS R01 NS085165NINDS NIH HHS R21 NS096538
6 · The paper itself

Abstract

Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here, we show that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O

Indexed as

AnimalsCell RespirationChlorocebus aethiopsCOS CellsDynaminsElectron Transport Complex IFibroblastsGTP PhosphohydrolasesHumansMiceMice, KnockoutMicrotubule-Associated ProteinsMitochondriaMitochondrial ProteinsNADNeurons3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinoneDNM1L protein, humanDnm1l protein, mouseDynaminsElectron Transport Complex IGTP PhosphohydrolasesMicrotubule-Associated ProteinsMitochondrial ProteinsNADNdi1 protein, S cerevisiaeQuinazolinonesReactive Oxygen SpeciesSaccharomyces cerevisiae Proteinsbioenergeticsbrainfissionfragmentationmitochondrianeuronrespirationreverse electron transfersuccinatesuperoxide

Identifiers

PMID28350990
PMCPMC5398851
OpenAlexW2602846991

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.