Evidence map›Paper›PMID 28350981›Full record

ArticleDevelopmental cell2017

Asymmetric Notch Amplification to Secure Stem Cell Identity.

Anthony M Rossi, Claude Desplan

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Cell cycle-dependent cues regulate temporal patterning of thebioRxiv : the preprint server for biology · 2025
    Article
  4. Asymmetric Cell Division and Tumor Heterogeneity.Frontiers in cell and developmental biology · 2022
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Anthony M RossiDepartment of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.
Claude DesplanDepartment of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA. Electronic address: cd38@nyu.edu.

Funding

Vision Core Grant- Design and Fabrication ModuleP30EY013079 · NEI · NEW YORK UNIVERSITY · PI MOVSHON, J ANTHONY · 2000 to 2025
$14.2M
Signaling from photoreceptors to the optic lobesR01EY013012 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2024
$9.4M
TRAINING PROGRAM IN DEVELOPMENTAL GENETICS.T32HD007520 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TREISMAN, JESSICA E · 1999 to 2023
$3.9M
Neurogenesis of the Drosophila Mushroom BodiesR21NS095288 · NINDS · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 2015 to 2016
$428k
NEI NIH HHS P30 EY013079NEI NIH HHS R01 EY013012NICHD NIH HHS T32 HD007520NINDS NIH HHS R21 NS095288
6 · The paper itself

Abstract

Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.

Indexed as

Receptors, NotchStem CellsCell DifferentiationNeural Stem CellsSignal TransductionReceptors, Notch

Identifiers

PMID28350981
PMCPMC5490801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.