Evidence map›Paper›PMID 28350900›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017

Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group.

Sarah B Doernberg, Thomas P Lodise, Joshua T Thaden, Jose M Munita, Sara E Cosgrove, Cesar A Arias, Helen W Boucher, G Ralph Corey, Franklin D Lowy, Barbara Murray and 3 more

Abstract readReview
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. NewTheScientificWorldJournal · 2025
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. A case study onJAC-antimicrobial resistance · 2020
    Review
  19. Article
  20. A new simplified predictive model for mortality in methicillin-resistant Staphylococcus aureus bacteremia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sarah B DoernbergDivision of Infectious Diseases, University of California, San Francisco.
Thomas P LodiseAlbany College of Pharmacy and Health Sciences, New York.
Joshua T ThadenDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina.
Jose M MunitaDivision of Infectious Diseases, University of Texas Health Sciences Center, Houston.
Sara E CosgroveDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Cesar A AriasCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, University of Texas Health Sciences Center, Houston.
Helen W BoucherDivision of Infectious Diseases, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts.
G Ralph CoreyDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina.
Franklin D LowyDivision of Infectious Diseases, Columbia University Medical Center, New York, New York.
Barbara MurrayDivision of Infectious Diseases, University of Texas Health Sciences Center, Houston.
Loren G MillerDivision of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California; and.
Thomas L HollandDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina.
Gram-Positive Committee of the Antibacterial Resistance Leadership Group (ARLG)

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
Molecular Mechanisms Of Daptomycin Resistance In EnterococciR01AI093749 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2011 to 2015
$1.9M
NIAID NIH HHS R01 AI093749NIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

Antimicrobial resistance in gram-positive bacteria remains a challenge in infectious diseases. The mission of the Gram-Positive Committee of the Antibacterial Resistance Leadership Group (ARLG) is to advance knowledge in the prevention, management, and treatment of these challenging infections to improve patient outcomes. Our committee has prioritized projects involving methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) due to the scope of the medical threat posed by these pathogens. Approved ARLG projects involving gram-positive pathogens include (1) a pharmacokinetics/pharmacodynamics study to evaluate the impact of vancomycin dosing on patient outcome in MRSA bloodstream infection (BSI); (2) defining, testing, and validating innovative assessments of patient outcomes for clinical trials of MRSA-BSI; (3) testing new strategies for "step-down" antibiotic therapy for MRSA-BSI; (4) management of staphylococcal BSIs in neonatal intensive care units; and (5) defining the impact of VRE bacteremia and daptomycin susceptibility on patient outcomes. This article outlines accomplishments, priorities, and challenges for research of infections caused by gram-positive organisms.

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsGram-Positive BacteriaGram-Positive Bacterial InfectionsHumansLeadershipResearchAnti-Bacterial Agentsbloodstream infectionClostridium difficile infection.gram-positive bacteriaStaphylococcus aureusvancomycin-resistant enterococci

Identifiers

PMID28350900
PMCPMC5850444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.