ArticlePloS one2017
RNA-sequence analysis of gene expression from honeybees (Apis mellifera) infected with Nosema ceranae.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Meta-Analysis and Experimental Evidence Reveal No Impact of Nosema ceranae Infection on Honeybee Carbohydrate Consumption.Microbial ecology · 2025Pooled it
- Pilot Study of Grape Pomace Extract Impact onInsects · 2026Article
- Wake Up and Smell the Infected Bees: Volatile Cues ofEcology and evolution · 2026Article
- Metagenomic and gene expression patterns in declining commercial honey bee colonies.Scientific reports · 2026Article
- Interactions between ionizing radiation and Vairimorpha (Nosema) ceranae on the honeybee, Apis mellifera L.PloS one · 2026Article
- Vector Potential ofInsects · 2025Article
- Article
- Comprehensive expression data for two honey bee species, Apis mellifera and Apis cerana japonica.Scientific data · 2025Article
- Omics in mini-livestock: a genomic perspective on the future of sustainable food systems.Frontiers in genetics · 2025Review
- Article
- Potential of Wormwood and Oak Bark-Based Supplement in Health Improvement ofAnimals : an open access journal from MDPI · 2024Article
- Beneficial Bacteria and Plant Extracts Promote Honey Bee Health and Reduce Nosema ceranae Infection.Probiotics and antimicrobial proteins · 2024Article
- Cellular heterogeneity of the developing worker honey bee (Apis mellifera) pupa: a single cell transcriptomics analysis.G3 (Bethesda, Md.) · 2023Article
- Review
- The FungusMicroorganisms · 2023Article
- Current Knowledge on Bee Innate Immunity Based on Genomics and Transcriptomics.International journal of molecular sciences · 2022Review
- Article
- Effect of amide protoporphyrin derivatives on immune response in Apis mellifera.Scientific reports · 2022Article
- Transcriptome ofInsects · 2022Article
- Comparative Transcriptome Investigation ofInsects · 2022Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honeybees (Apis mellifera) are constantly subjected to many biotic stressors including parasites. This study examined honeybees infected with Nosema ceranae (N. ceranae). N. ceranae infection increases the bees energy requirements and may contribute to their decreased survival. RNA-seq was used to investigate gene expression at days 5, 10 and 15 Post Infection (P.I) with N. ceranae. The expression levels of genes, isoforms, alternative transcription start sites (TSS) and differential promoter usage revealed a complex pattern of transcriptional and post-transcriptional gene regulation suggesting that bees use a range of tactics to cope with the stress of N. ceranae infection. N. ceranae infection may cause reduced immune function in the bees by: (i)disturbing the host amino acids metabolism (ii) down-regulating expression of antimicrobial peptides (iii) down-regulation of cuticle coatings and (iv) down-regulation of odorant binding proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.