ArticlePLoS biology2017
A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
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- Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion.Nature communications · 2024Article
- Upregulation of Tribbles decreases body weight and increases sleep duration.Disease models & mechanisms · 2023Article
- Central and Peripheral Clock Control of Circadian Feeding Rhythms.Journal of biological rhythms · 2021Article
- A large chromosomal inversion shapes gene expression in seaweed flies (Evolution letters · 2021Article
- Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster.BMC biology · 2021Article
- Transcriptome Analysis of NPFR Neurons Reveals a Connection Between Proteome Diversity and Social Behavior.Frontiers in behavioral neuroscience · 2021Article
- Neural circuit mechanisms encoding motivational states in Drosophila.Current opinion in neurobiology · 2020Review
- Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception.Annual review of physiology · 2020Review
- The Role of Peptide Hormones in Insect Lipid Metabolism.Frontiers in physiology · 2020Review
- Peripheral Expression of Mutant Huntingtin is a Critical Determinant of Weight Loss and Metabolic Disturbances in Huntington's Disease.Scientific reports · 2019Article
- Neural basis of hunger-driven behaviour in Drosophila.Open biology · 2019Review
- Regulation of Feeding and Metabolism by Neuropeptide F and Short Neuropeptide F in Invertebrates.Frontiers in endocrinology · 2019Review
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- An appetite for understanding appetite.PLoS biology · 2017Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we show that the enzymatic cofactor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila. BH4 biosynthesis requires the sequential action of the conserved enzymes Punch, Purple, and Sepiapterin Reductase (Sptr). Although we observe increased feeding upon loss of Punch and Purple in the adult fat body, loss of Sptr must occur in the brain. We found Sptr expression is required in four adult neurons that express neuropeptide F (NPF), the fly homologue of the vertebrate appetite regulator neuropeptide Y (NPY). As expected, feeding flies BH4 rescues the loss of Punch and Purple in the fat body and the loss of Sptr in NPF neurons. Mechanistically, we found BH4 deficiency reduces NPF staining, likely by promoting its release, while excess BH4 increases NPF accumulation without altering its expression. We thus show that, because of its physically distributed biosynthesis, BH4 acts as a fat-derived signal that induces satiety by inhibiting the activity of the NPF neurons.
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