ArticleBritish journal of cancer2017
Dependence of cancer risk from environmental exposures on underlying genetic susceptibility: an illustration with polycyclic aromatic hydrocarbons and breast cancer.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Endocrine-disrupting chemicals and breast cancer: a meta-analysis.Frontiers in oncology · 2023Pooled it
- DNA repair phenotype and cancer risk: a systematic review and meta-analysis of 55 case-control studies.Scientific reports · 2022Pooled it
- Relationship between particulate matter exposure and female breast cancer incidence and mortality: a systematic review and meta-analysis.International archives of occupational and environmental health · 2021Pooled it
- Environmental exposures and breast cancer risk in the context of underlying susceptibility: A systematic review of the epidemiological literature.Environmental research · 2020Pooled it
- Is breast cancer a result of epigenetic responses to traffic-related air pollution? A review of the latest evidence.Epigenomics · 2019Pooled it
- The exposome and inflammatory bowel disease: a framework for primary and primordial prevention.Nature reviews. Gastroenterology & hepatology · 2026Review
- ToxBase: A Multidimensional ToxCast Reference Database for High-Throughput Human Exposome Analysis.Environmental science & technology · 2026Article
- Article
- Polycyclic aromatic hydrocarbon derivative 3-hydroxybenz[a]anthracene promotes the progression of T47D breast cancer cells by modulating relevant protein expression.Frontiers in cell and developmental biology · 2026Article
- Article
- Early onset cancer trends and the persistently higher burden of cancer in young women.The oncologist · 2025Article
- Aromatics from fossil fuels and breast cancer.iScience · 2025Review
- Advancing environmental epidemiologic methods to confront the cancer burden.American journal of epidemiology · 2025Article
- Chemical pollution drives taxonomic and functional shifts in marine sediment microbiome, influencing benthic metazoans.ISME communications · 2025Article
- Dioxins do not only bind to AHR but also team up with EGFR at the cell-surface: a novel mode of action of toxicological relevance?EXCLI journal · 2025Review
- Exposure to air pollutants and breast cancer risk: mediating effects of metabolic health biomarkers in a nested case-control study within the E3N-Generations cohort.Breast cancer research : BCR · 2024Article
- Plasma metabolomics profiles and breast cancer risk.Breast cancer research : BCR · 2024Article
- Review
- High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage.Environmental science & technology · 2024Review
- Breast Cancer Exposomics.Life (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMost studies of environmental risk factors and breast cancer are conducted using average risk cohorts.
methodsWe examined the association between polycyclic aromatic hydrocarbon (PAH)-albumin adducts in bloods from baseline and breast cancer risk in a prospective nested case-control study (New York site of the BCFR, 80 cases and 156 controls). We estimated the 10-year absolute breast cancer risk by a risk model that uses pedigree information (BOADICEA) and evaluated whether the increased risk from PAH differed by absolute risk.
resultsWomen with detectable levels of PAH had a twofold association with breast cancer risk (odds ratio (OR)=2.04; 95% CI=1.06-3.93) relative to women with non-detectable levels. The association increased with higher levels of PAH (⩾median) and by a higher level of absolute breast cancer risk (10-year risk ⩾3.4%: OR=4.09, 95% CI=1.38-12.13).
conclusionsThese results support that family-based cohorts can be an efficient way to examine gene-environment interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.