Evidence map›Paper›PMID 28350785›Full record

ArticleBritish journal of cancer2017

The PICTURE study: diagnostic accuracy of multiparametric MRI in men requiring a repeat prostate biopsy.

Lucy A M Simmons, Abi Kanthabalan, Manit Arya, Tim Briggs, Dean Barratt, Susan C Charman, Alex Freeman, James Gelister, David Hawkes, Yipeng Hu and 8 more

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05241236 recruitingnot on this mapstarted 2020, after this paper: background citation

Office Based MRI/Ultrasound Guided Prostate Cancer Ablation: Outcomes Registry

Typeobservational_patient_registrySponsorUrological Research Network, LLCRan2020 to 2038Enrolled5,000ConditionsNeoplasms Prostate, Cancer of the ProstateArmsImage Fusion (MR/US) Software Registration Guided Laser Ablation of Prostate Cancer
NCT05698576 narecruitingnot on this mapstarted 2022, after this paper: background citation

TRANBERG® Transperineal MR/US Focalyx Fusion Laser--Induced Thermal Therapy in the Office Setting Under Local Anesthesia

TypeinterventionalSponsorUrological Research Network, LLCRan2022 to 2033Enrolled20ConditionsProstate Cancer, Adverse Effects Surgery, MRI, UltrasoundArmsTRANBERG® Transperineal Fusion Laser--Induced Thermal Therapy of Prostate Cancer (TPF-LITT)
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 106 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Lucy A M SimmonsDivision of Surgery and Interventional Science, University College London, Faculty of Medical Sciences, 21 University Street, London WC1E 7PN, UK.
Abi KanthabalanDivision of Surgery and Interventional Science, University College London, Faculty of Medical Sciences, 21 University Street, London WC1E 7PN, UK.
Manit AryaDepartment of Urology, UCLH NHS Foundation Trust, London, UK.
Tim BriggsDepartment of Urology, UCLH NHS Foundation Trust, London, UK.
Dean BarrattCentre for Medical Imaging and Computing, Department of Computer Science, University College London, London, UK.
Susan C CharmanDepartment of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Alex FreemanDepartment of Pathology, UCLH NHS Foundation Trust London, UK.
James GelisterDepartment of Urology, The Royal Free London NHS Foundation Trust, London, UK.
David HawkesCentre for Medical Imaging and Computing, Department of Computer Science, University College London, London, UK.
Yipeng HuCentre for Medical Imaging and Computing, Department of Computer Science, University College London, London, UK.
Charles JamesonDepartment of Pathology, UCLH NHS Foundation Trust London, UK.
Neil McCartanDivision of Surgery and Interventional Science, University College London, Faculty of Medical Sciences, 21 University Street, London WC1E 7PN, UK.
Caroline M MooreDivision of Surgery and Interventional Science, University College London, Faculty of Medical Sciences, 21 University Street, London WC1E 7PN, UK.
Shonit PunwaniDepartment of Radiology, UCLH NHS Foundation Trust, London, UK.
Navin RamachandranDepartment of Radiology, UCLH NHS Foundation Trust, London, UK.
Jan van der MeulenDepartment of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Mark EmbertonDivision of Surgery and Interventional Science, University College London, Faculty of Medical Sciences, 21 University Street, London WC1E 7PN, UK.
Hashim U AhmedDivision of Surgery and Interventional Science, University College London, Faculty of Medical Sciences, 21 University Street, London WC1E 7PN, UK.
University College Hospital · GBUniversity College London · GBRoyal College of Surgeons of England · GBRoyal Free London NHS Foundation Trust · GBImperial College Healthcare NHS Trust · GB

Funding

Focal HIFU Ablation of Prostate Cancer Using Advanced Ultrasound GuidanceR01CA135089 · NCI · RIVERSIDE RESEARCH INSTITUTE · PI FELEPPA, ERNEST JOSEPH, SANGHVI, NARENDRA T · 2010 to 2013
$2.1M
Cancer Research UK 16463Department of Health 09/22/67Medical Research Council G0701302NCI NIH HHS R01 CA135089
6 · The paper itself

Abstract

backgroundTransrectal prostate biopsy has limited diagnostic accuracy. Prostate Imaging Compared to Transperineal Ultrasound-guided biopsy for significant prostate cancer Risk Evaluation (PICTURE) was a paired-cohort confirmatory study designed to assess diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) in men requiring a repeat biopsy.

methodsAll underwent 3 T mpMRI and transperineal template prostate mapping biopsies (TTPM biopsies). Multiparametric MRI was reported using Likert scores and radiologists were blinded to initial biopsies. Men were blinded to mpMRI results. Clinically significant prostate cancer was defined as Gleason ⩾4+3 and/or cancer core length ⩾6 mm.

resultsTwo hundred and forty-nine had both tests with mean (s.d.) age was 62 (7) years, median (IQR) PSA 6.8 ng ml (4.98-9.50), median (IQR) number of previous biopsies 1 (1-2) and mean (s.d.) gland size 37 ml (15.5). On TTPM biopsies, 103 (41%) had clinically significant prostate cancer. Two hundred and fourteen (86%) had a positive prostate mpMRI using Likert score ⩾3; sensitivity was 97.1% (95% confidence interval (CI): 92-99), specificity 21.9% (15.5-29.5), negative predictive value (NPV) 91.4% (76.9-98.1) and positive predictive value (PPV) 46.7% (35.2-47.8). One hundred and twenty-nine (51.8%) had a positive mpMRI using Likert score ⩾4; sensitivity was 80.6% (71.6-87.7), specificity 68.5% (60.3-75.9), NPV 83.3% (75.4-89.5) and PPV 64.3% (55.4-72.6).

conclusionsIn men advised to have a repeat prostate biopsy, prostate mpMRI could be used to safely avoid a repeat biopsy with high sensitivity for clinically significant cancers. However, such a strategy can miss some significant cancers and overdiagnose insignificant cancers depending on the mpMRI score threshold used to define which men should be biopsied.

Indexed as

AgedBiopsyCohort StudiesHumansImage-Guided BiopsyMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesProstateProstatic NeoplasmsUltrasound, High-Intensity Focused, Transrectal

Identifiers

PMID28350785
PMCPMC5418442
OpenAlexW2599026597

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.