Evidence map›Paper›PMID 28350777›Full record

ArticlePediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association2017

Understanding Brain Reorganization in Infants With Perinatal Stroke Through Neuroexcitability and Neuroimaging.

Chao-Ying Chen, Michael Georgieff, Jed Elison, Mo Chen, James Stinear, Bryon Mueller, Raghavendra Rao, Kyle Rudser, Bernadette Gillick

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05013736 (Perinatal Stroke), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05013736 recruitingnot on this mapstarted 2022, after this paper: background citation

Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery Through Neuroexcitability, Neuroimaging and Motor Development

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2022 to 2026Enrolled65ConditionsPerinatal StrokeArmsMagnetic Resonance Imaging, Behavioral Assessments, Non invasive Transcranial Magnetic Stimulation
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chao-Ying ChenDepartment of Physical Medicine and Rehabilitation (Drs C-Y Chen and Gillick), Department of Pediatrics (Drs Georgieff and Rao), Institute of Child Development (Dr Elison), Institute for Engineering in Medicine (Dr M Chen), and Department of Psychiatry (Dr Mueller), University of Minnesota, Minneapolis; Department of Exercise Sciences (Dr Stinear), University of Auckland, New Zealand; and Clinical and Translational Science Institute (Dr Rudser), University of Minneapolis, Minnesota.
Michael Georgieff
Jed Elison
Mo Chen
James Stinear
Bryon Mueller
Raghavendra Rao
Kyle Rudser
Bernadette Gillick
Minneapolis Institute of Arts · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)KL2TR000113 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$5.4M
Novel Neuromodulatory Intervention in the Rehabilitation of Pediatric HemiparesisK01HD078484 · NICHD · UNIVERSITY OF MINNESOTA · PI GILLICK, BERNADETTE THERESE · 2014 to 2018
$654k
NCATS NIH HHS KL2 TR000113NCATS NIH HHS UL1 TR000114NICHD NIH HHS K01 HD078484
6 · The paper itself

Abstract

purposeThe primary aim of this proposed study is to evaluate brain reorganization patterns in infants with perinatal stroke between 3 and 5 months of age using transcranial magnetic stimulation and magnetic resonance imaging, with the addition of the General Movements Assessment. A secondary aim is to demonstrate feasibility and safety of infant-appropriate brain assessment protocols.

methodsTen infants with perinatal stroke will be enrolled. In this exploratory study, infants will first receive magnetic resonance imaging scanning during natural sleep to examine their corticospinal tract integrity. Infants will then receive transcranial magnetic stimulation to assess their corticomotor excitability. A General Movements Assessment video of at least 5 minutes will also be recorded. DISCUSSION: Study results will enhance our understanding of brain reorganization in infants with perinatal stroke. We expect these results will also guide the development of early interventions designed to mitigate maladaptive neuroplastic changes and improve long-term motor outcomes.

Indexed as

Magnetic Resonance ImagingTranscranial Magnetic StimulationBrainCross-Sectional StudiesFemaleHumansInfantMaleMotor ActivityPyramidal TractsStroke

Identifiers

PMID28350777
PMCPMC5560124
OpenAlexW2601557463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.