Observational studyCritical care medicine2017
Disassociating Lung Mechanics and Oxygenation in Pediatric Acute Respiratory Distress Syndrome.
Observational study in Critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03768921 (Use of Electrical Impedance Tomography in Children With Syndrome of Acute Respiratory Disorder), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Electrical Impedance Tomography in Children With Syndrome of Acute Respiratory Disorder
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Validation of Lung Ultrasound Score for Disease Severity and Outcomes in Pediatric Acute Respiratory Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Observational
- Article
- Re-evaluating early high-frequency oscillatory ventilation in moderate-to-severe pediatric ARDS: evidence from a genetic matching analysis.Frontiers in medicine · 2026Article
- Acute Respiratory Distress Syndrome Definitions in Adults and Children: A Comparative Narrative Review.Journal of clinical medicine · 2025Review
- The Impact of Increased PEEP on Hemodynamics, Respiratory Mechanics, and Oxygenation in Pediatric ARDS.Respiratory care · 2024Article
- Mechanical power and normalized mechanical power in pediatric acute respiratory distress syndrome.Frontiers in pediatrics · 2024Article
- Association Between Mortality and Ventilator Parameters in Children With Respiratory Failure on ECMO.Respiratory care · 2023Article
- Alveolar dead space fraction is not associated with early RV systolic dysfunction in pediatric ARDS.Pediatric pulmonology · 2023Article
- Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023Review
- Mechanical power is associated with weaning outcome in critically ill mechanically ventilated patients.Scientific reports · 2022Article
- The Association Between Oxygenation Status at 24 h After Diagnosis of Pulmonary Acute Respiratory Distress Syndrome and the 30-Day Mortality among Pediatric Oncological Patients.Frontiers in pediatrics · 2022Article
- Potential therapeutics in pediatric acute respiratory distress syndrome: what does the immune system have to offer? A narrative review.Translational pediatrics · 2021Review
- Airway Resistance and Respiratory Compliance in Children with Acute Viral Bronchiolitis Requiring Mechanical Ventilation Support.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Energy transmission in mechanically ventilated children: a translational study.Critical care (London, England) · 2020Article
- Adding Continuous Vital Sign Information to Static Clinical Data Improves the Prediction of Length of Stay After Intubation: A Data-Driven Machine Learning Approach.Respiratory care · 2020Article
- The impact of high frequency oscillatory ventilation on mortality in paediatric acute respiratory distress syndrome.Critical care (London, England) · 2020Article
- Knowledge and Practice of the Concept of Driving Pressure: A Survey of Pediatric Intensivists in Brazil.Journal of pediatric intensive care · 2019Article
- Specific Viral Etiologies Are Associated With Outcomes in Pediatric Acute Respiratory Distress Syndrome.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Article
- Association Between Tidal Volumes Adjusted for Ideal Body Weight and Outcomes in Pediatric Acute Respiratory Distress Syndrome.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesBoth oxygenation and peak inspiratory pressure are associated with mortality in pediatric acute respiratory distress syndrome. Since oxygenation and respiratory mechanics are linked, it is difficult to identify which variables, pressure or oxygenation, are independently associated with outcome. We aimed to determine whether respiratory mechanics (peak inspiratory pressure, positive end-expiratory pressure, ΔP [PIP minus PEEP], tidal volume, dynamic compliance [Cdyn]) or oxygenation (PaO2/FIO2) was associated with mortality.
designProspective, observational, cohort study.
settingUniversity affiliated PICU. PATIENTS: Mechanically ventilated children with acute respiratory distress syndrome (Berlin).
interventionsNone. MEASUREMENTS AND MAIN
resultsPeak inspiratory pressure, positive end-expiratory pressure, ΔP, tidal volume, Cdyn, and PaO2/FIO2 were collected at acute respiratory distress syndrome onset and at 24 hours in 352 children between 2011 and 2016. At acute respiratory distress syndrome onset, neither mechanical variables nor PaO2/FIO2 were associated with mortality. At 24 hours, peak inspiratory pressure, positive end-expiratory pressure, ΔP were higher, and Cdyn and PaO2/FIO2 lower, in nonsurvivors. In multivariable logistic regression, PaO2/FIO2 at 24 hours and ΔPaO2/FIO2 (change in PaO2/FIO2 over the first 24 hr) were associated with mortality, whereas pressure variables were not. Both oxygenation and pressure variables were associated with duration of ventilation in multivariable competing risk regression.
conclusionsImprovements in oxygenation, but not in respiratory mechanics, were associated with lower mortality in pediatric acute respiratory distress syndrome. Future trials of mechanical ventilation in children should focus on oxygenation (higher PaO2/FIO2) rather than lower peak inspiratory pressure or ΔP, as oxygenation was more consistently associated with outcome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.