Evidence map›Paper›PMID 28350401›Full record

Trial reportTranslational psychiatry2017

Systemic inflammation enhances stimulant-induced striatal dopamine elevation.

J R Petrulli, B Kalish, N B Nabulsi, Y Huang, J Hannestad, E D Morris

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Dyskinesia-hyperpyrexia syndrome in Parkinson's disease: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Dopamine, Immunity, and Disease.Pharmacological reviews · 2023
    Review
  11. Review
  12. The crucial role of prolactin-lactogenic hormone in Covid-19.Molecular and cellular biochemistry · 2022
    Review
  13. Harmonization of [EJNMMI physics · 2022
    Article
  14. Article
  15. Review
  16. Clinical practice and epidemiology in mental health : CP & EMH · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

J R PetrulliDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
B KalishDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
N B NabulsiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Y HuangDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
J HannestadDenali Therapeutics Inc., South San Francisco, CA, USA.
E D MorrisDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Yale University · USDenali Therapeutics (United States) · US

Funding

Endotoxin-induced inflammation affects striatal dopamine: A raclopride PET studyR21AG043702 · NIA · YALE UNIVERSITY · PI MORRIS, EVAN D · 2013 to 2014
$458k
NIA NIH HHS R21 AG043702
6 · The paper itself

Abstract

Changes in the mesolimbic dopamine (DA) system are implicated in a range of neuropsychiatric conditions including addiction, depression and schizophrenia. Dysfunction of the neuroimmune system is often comorbid with such conditions and affects similar areas of the brain. The goal of this study was to use positron emission tomography with the dopamine D

Indexed as

AdultCarbon RadioisotopesCase-Control StudiesCentral Nervous System StimulantsDopamineDopamine AntagonistsFemaleHealthy VolunteersHumansInflammationInterleukin-6Interleukin-8LipopolysaccharidesMaleMethylphenidateNeostriatumCarbon RadioisotopesCentral Nervous System StimulantsCXCL8 protein, humanDopamineDopamine AntagonistsDRD2 protein, humanIL6 protein, humanInterleukin-6Interleukin-8LipopolysaccharidesMethylphenidateRacloprideRadiopharmaceuticalsReceptors, Dopamine D2TNF protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID28350401
PMCPMC5404612
OpenAlexW2602661268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.