ArticleTranslational psychiatry2017
Genetic effects influencing risk for major depressive disorder in China and Europe.
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Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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43citing papers in PubMed, 3 pooled it
9.0field-weighted citation impact, top 2% of its field
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Polygenic Scores for ADHD: A Meta-Analysis.Research on child and adolescent psychopathology · 2021Pooled it
- Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Pooled it
- The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Pooled it
- Peripheral transcriptomic aging acceleration in major depressive disorder: the mediating role of insular cortex alterations.Psychological medicine · 2026Article
- MCEEGNet: a multi-cue EEG network for quantitative assessment of depression using emotional stimuli-induced EEG signals.Frontiers in artificial intelligence · 2026Article
- Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder.Behavioral and brain functions : BBF · 2025Article
- Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium.bioRxiv : the preprint server for biology · 2025Article
- Trans-ancestry Genome-Wide Analyses in UK Biobank Yield Novel Risk Loci for Major Depression.medRxiv : the preprint server for health sciences · 2025Article
- Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal.Psychological medicine · 2024Article
- Inflammation and immune system pathways as biological signatures of adolescent depression-the IDEA-RiSCo study.Translational psychiatry · 2024Article
- Incorporating genetic similarity of auxiliary samples into eGene identification under the transfer learning framework.Journal of translational medicine · 2024Article
- Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.Nature genetics · 2024Article
- Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes.BMC genomics · 2023Article
- Similarity and diversity of genetic architecture for complex traits between East Asian and European populations.BMC genomics · 2023Article
- Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing.Journal of translational medicine · 2022Article
- Multivariate genome-wide association study of depression, cognition, and memory phenotypes and validation analysis identify 12 cross-ethnic variants.Translational psychiatry · 2022Article
- DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses.Genome medicine · 2022Article
- The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder.Psychoradiology · 2022Article
- Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations.Human genetics · 2021Article
- Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.Molecular psychiatry · 2021Article
Corrections and comments
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Authors and funding
97 authors at 20 institutions in 10 countries.
T B BigdeliDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
S RipkeDepartment of Psychiatry, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany.
R E PetersonDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
M TrzaskowskiInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
S-A BacanuDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
A AbdellaouiDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
T F M AndlauerDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
A T F BeekmanDepartment of Psychiatry, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
K BergerInstitute of Epidemiology and Social Medicine, University of Muenster, Münster, Germany.
D H R BlackwoodDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
D I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
G BreenKing's College London, NIHR BRC for Mental Health, London, UK.
H N ButtenschønDepartment of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark.
E M ByrneQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
S CichonDepartment of Biomedicine, University of Basel, Basel, Switzerland.
T-K ClarkeDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
B Couvy-DuchesneQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
N CraddockDepartment of Psychological Medicine, Cardiff University, Cardiff, UK.
E J C de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
F DegenhardtInstitute of Human Genetics, University of Bonn, Bonn, Germany.
E C DunnStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
A C EdwardsDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
A H FanousDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
A J ForstnerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
J FrankDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
M GillDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland.
S D GordonDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
H J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
S P HamiltonDepartment of Psychiatry, Kaiser-Permanente Northern California, San Fransisco, CA, USA.
O HardimanInstitute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
C HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
A C HeathDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St Louis, MO, USA.
A K HendersQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
S HermsInstitute of Human Genetics, University of Bonn, Bonn, Germany.
I B HickieBrain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
P HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.
G HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
J-J HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
M IsingMax Planck Institute of Psychiatry, Munich, Germany.
R JansenDepartment of Psychiatry, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
S KloiberMax Planck Institute of Psychiatry, Munich, Germany.
J A KnowlesDepartment of Psychiatry and The Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
M LangDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Q S LiNeuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.
S LucaeMax Planck Institute of Psychiatry, Munich, Germany.
D J MacIntyreDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
P A F MaddenDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St Louis, MO, USA.
N G MartinDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
P J McGrathDepartment of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA.
P McGuffinKing's College London, MRC Social Genetic and Developmental Psychiatry Centre, London, UK.
A M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
S E MedlandDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
D MehtaQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
C M MiddeldorpDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Y MilaneschiDepartment of Psychiatry, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
G W MontgomeryInstitute for Molecular Biology, University of Queensland, Brisbane, QLD, Australia.
O MorsPsychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
B Müller-MyhsokDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
M NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
D R NyholtInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
M M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
M J OwenMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK.
B W J H PenninxDepartment of Psychiatry, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
M L PergadiaCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
R H PerlisDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
W J PeyrotDepartment of Psychiatry, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
D J PorteousMedical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK.
J B PotashDepartment of Psychiatry, University of Iowa, Iowa, IA, USA.
J P RiceDepartment of Psychiatry, Washington University in Saint Louis, St Louis, MO, USA.
M RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
B P RileyDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
M RiveraDepartment of Biochemistry and Molecular Biology II, Institute of Neurosciences, Center for Biomedical Research, University of Granada, Granada, Spain.
R SchoeversDepartment of Psychiatry, University of Groningen, University of Medical Center Groningen, Groningen, The Netherlands.
T G SchulzeDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
J ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
S I ShynDivision of Psychiatry, Group Health, Seattle, WA, USA.
J H SmitDepartment of Psychiatry, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
J W SmollerStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
F StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
J StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
A TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
J TreutleinDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
S Van der AuweraDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
G van GrootheestDepartment of Psychiatry, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
A M van HemertDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
H VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
B T WebbDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
M M WeissmanDivision of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.
J WellmannInstitute of Epidemiology and Social Medicine, University of Muenster, Münster, Germany.
G WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
S H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
D F LevinsonPsychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
C M LewisKing's College London, MRC Social Genetic and Developmental Psychiatry Centre, London, UK.
N R WrayInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
J FlintMerton College, University of Oxford, Oxford, UK.
P F SullivanMedical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
K S KendlerDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
GGZ inGeest · NLVirginia Commonwealth University · USUniversity of Queensland · AUVrije Universiteit Amsterdam · NLUniversitätsmedizin Greifswald · DECentral Institute of Mental Health · DEMax Planck Institute of Psychiatry · DEUniversity of Edinburgh · GBKing's College London · GBQIMR Berghofer Medical Research Institute · AUUniversity Hospital Heidelberg · DEWashington University in St. Louis · USBroad Institute · USCardiff University · GBColumbia University · USLife & Brain (Germany) · DEMRC Institute of Genetics and Molecular Medicine · GBTrinity College Dublin · IEUniversity of Bonn · DEUniversity of Münster · DE
Funding
Informatics for Integrating Biology/ the Bedside (RMI)U54LM008748 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI KOHANE, ISAAC S. · 2004 to 2013
$39.0MAN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORKU54RR020278 · NCRR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2004 to 2008
$14.4MInternational Cohort Collection for Bipolar DisorderR01MH085542 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SMOLLER, JORDAN W · 2008 to 2012
$10.7MTHE GENETICS OF VULNERABILITY TO NICOTINE ADDICTIONSR01DA012854 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2000 to 2013
$10.4MPharmacogenomics of Antidepressant ResponseR01MH072802 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAMILTON, STEVEN P. · 2005 to 2008
$4.6MMolecular Epidemiology of Alcoholism 3 - EDAC FamiliesR01AA013321 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2001 to 2005
$4.3MGENETICS OF RECURRENT EARLY-ONSET DEPRESSIONR01MH061686 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI LEVINSON, DOUGLAS FREDERICK · 1999 to 2008
$3.8MGENETICS OF EARLY-ONSET MAJOR DEPRESSIONR01MH060912 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI WEISSMAN, MYRNA M · 1999 to 2008
$3.3MMolecular Epidemiology of Alcoholism 2- Big SibshipsR01AA013320 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2003 to 2007
$3.1MGENETICS OF EARLY ONSET DEPRESSIONR01MH059552 · NIMH · JOHNS HOPKINS UNIVERSITY · PI POTASH, JAMES B. · 1999 to 2008
$2.8MGenetic Epidemiology of Pathological GamblingR01MH066206 · NIMH · UNIVERSITY OF MISSOURI-COLUMBIA · PI SLUTSKE, WENDY S · 2003 to 2007
$2.5MMolecular Epidemiology of Alcoholism 1: Candidate GeneR01AA013326 · NIAAA · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI MARTIN, NICHOLAS G · 2001 to 2005
$2.1MChief Scientist OfficeMedical Research Council MC_PC_U127561128Medical Research Council MR/K026992/1Medical Research Council MR/L010305/1NCRR NIH HHS U54 RR020278NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA013326NIAAA NIH HHS R01 AA014041NIDA NIH HHS K08 DA019951NIDA NIH HHS R01 DA012854NIDA NIH HHS R56 DA012854NIMH NIH HHS K01 MH102403NIMH NIH HHS N01 MH090003NIMH NIH HHS R01 MH059541NIMH NIH HHS R01 MH059542NIMH NIH HHS R01 MH059552NIMH NIH HHS R01 MH060912NIMH NIH HHS R01 MH061686NIMH NIH HHS R01 MH066206NIMH NIH HHS R01 MH072802NIMH NIH HHS R01 MH075131NIMH NIH HHS R01 MH081802NIMH NIH HHS R01 MH085542NIMH NIH HHS R01 MH086026NIMH NIH HHS R01 MH100549NIMH NIH HHS U01 MH094421NLM NIH HHS U54 LM008748Wellcome Trust 104036
Abstract
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30-40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects. We determined the fraction of SNPs displaying consistent directions of effect, assessed the significance of polygenic risk scores and estimated the genetic correlation of MDD across ancestries. Subsequent trans-ancestry meta-analyses combined SNP-level evidence of association. Sign tests and polygenic score profiling weakly support an overlap of SNP effects between East Asian and European populations. We estimated the trans-ancestry genetic correlation of lifetime MDD as 0.33; female-only and recurrent MDD yielded estimates of 0.40 and 0.41, respectively. Common variants downstream of GPHN achieved genome-wide significance by Bayesian trans-ancestry meta-analysis (rs9323497; log
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Asian PeopleBayes TheoremCase-Control StudiesChinaEuropeFemaleGenetic Predisposition to DiseaseHumansMajor Depressive DisorderMaleMultifactorial InheritancePolymorphism, Single NucleotideWhite People
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