Evidence map›Paper›PMID 28350298›Full record

ArticleeLife2017

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression.

Viviana Anelli, Jacques A Villefranc, Sagar Chhangawala, Raul Martinez-McFaline, Eleonora Riva, Anvy Nguyen, Akanksha Verma, Rohan Bareja, Zhengming Chen, Theresa Scognamiglio and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
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  7. Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption.Toxicological sciences : an official journal of the Society of Toxicology · 2023
    Review
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  18. Tipping the Scales With Zebrafish to Understand Adaptive Tumor Immunity.Frontiers in cell and developmental biology · 2021
    Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Viviana AnelliDepartment of Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, United States.
Jacques A VillefrancDepartment of Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, United States.
Sagar ChhangawalaDepartment of Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, United States.
Raul Martinez-McFalineDepartment of Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, United States.
Eleonora RivaSection of Endocrinology, Department of Medical Science, University of Ferrara, Ferrara, Italy.
Anvy NguyenDepartment of Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, United States.
Akanksha VermaInstitute for Computational Biomedicine, Weill Cornell Medical College, New York City, United States.
Rohan BarejaInstitute for Computational Biomedicine, Weill Cornell Medical College, New York City, United States.
Zhengming ChenDepartment of Healthcare Policy & Research, Weill Cornell Medical College, New York City, United States.
Theresa ScognamiglioDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, United States.
Olivier ElementoInstitute for Computational Biomedicine, Weill Cornell Medical College, New York City, United States.
Yariv HouvrasDepartment of Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, United States.ORCID 0000-0003-0751-3215
NewYork–Presbyterian Hospital · USCornell University · USUniversity of Ferrara · IT

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
SPORE in Thyroid CancerP50CA172012 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI FAGIN, JAMES A · 2014 to 2018
$10.3M
Building personalized avatars of human cancer to predict response to therapyR21CA202540 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI HOUVRAS, YARIV J · 2016 to 2017
$406k
NCATS NIH HHS UL1 TR000457NCI NIH HHS P50 CA172012NCI NIH HHS R21 CA202540NCI NIH HHS R21 CA202540 01NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Thyroid cancer is common, yet the sequence of alterations that promote tumor formation are incompletely understood. Here, we describe a novel model of thyroid carcinoma in zebrafish that reveals temporal changes due to BRAF

Indexed as

MorphogenesisAnimalsDisease Models, AnimalGene DeletionGene Expression ProfilingGene Expression RegulationMutant ProteinsMutation, MissenseProto-Oncogene Proteins B-rafThyroid GlandThyroid HormonesThyroid NeoplasmsTwist-Related Protein 2ZebrafishMutant ProteinsProto-Oncogene Proteins B-rafThyroid HormonesTwist-Related Protein 2cancer biologyEMTepithelial cellsgene expressionhuman biologymedicineprotooncogeneszebrafish

Identifiers

PMID28350298
PMCPMC5389860
OpenAlexW2599053411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.